211 498

Cited 18 times in

Pathological Complete Remission of Pancreatic Cancer Following Neoadjuvant Chemoradiation Therapy; Not the End of Battles

DC Field Value Language
dc.contributor.author강창무-
dc.contributor.author김명진-
dc.contributor.author김호근-
dc.contributor.author성진실-
dc.contributor.author송시영-
dc.contributor.author이성환-
dc.contributor.author이우정-
dc.contributor.author황호경-
dc.date.accessioned2018-03-26T17:00:33Z-
dc.date.available2018-03-26T17:00:33Z-
dc.date.issued2015-
dc.identifier.issn0025-7974-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157070-
dc.description.abstractIn spite of controversial issues, pancreatectomy following neoadjuvant chemoradiation therapy (NeoCRT) has been applied in treating advanced pancreatic cancer. Cases of pathological complete remission (pCR) following NeoCRT is rare, and its long-term follow-up data are still lacking.From January 2000 to December 2012, medical records of the patients who underwent pancreatectomy for pancreatic ductal adenocarcinoma were retrospectively reviewed. Characteristics of the patients with pCR were summarized and their long-term follow-up data were analyzed.Among 86 patients with pancreatic cancer who underwent radical pancreatectomy following NeoCRT, 10 patients (11.6%) were reported to pCR. Nine out of 10 patients received gemcitabine-based chemoradiation therapy. Median pre-NeoCRT serum CA 19-9 was 313.5 U/ml, and post-NeoCRT serum CA 19-9 was 9.9 U/ml, which was shown to be significant difference between 2 serum CA 19-9 level (P = 0.005). Pylorus-preserving pancreaticoduodenectomy was done in 8 patients, and the others received distal pancreatosplenectomy. Postoperative chemotherapy was received in 6 patients. Disease-free survival was statistically superior in patients with pCR than patients without pCR (P < 0.05). However, 5 patients experienced cancer recurrence and no clinicopathologic variables including preoperative resectability could not predict the potential recurrence of tumor in patients with pCR (P > 0.05).pCR is rarely reported following NeoCRT, but this condition is not telling the cure of the disease. Early recurrence in the pattern of liver metastasis and peritoneal seeding can be expected. However, long-term survival could be maintained in patients without recurrence. Further investigation is necessary for predicting failure of treatment.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherLippincott Williams & Wilkins-
dc.relation.isPartOfMEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAntimetabolites, Antineoplastic/administration & dosage-
dc.subject.MESHAntimetabolites, Antineoplastic/adverse effects-
dc.subject.MESHCarcinoma, Pancreatic Ductal*/blood-
dc.subject.MESHCarcinoma, Pancreatic Ductal*/pathology-
dc.subject.MESHCarcinoma, Pancreatic Ductal*/therapy-
dc.subject.MESHChemotherapy, Adjuvant/methods*-
dc.subject.MESHDeoxycytidine/administration & dosage-
dc.subject.MESHDeoxycytidine/adverse effects-
dc.subject.MESHDeoxycytidine/analogs & derivatives*-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHDrug Monitoring/methods-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy/methods-
dc.subject.MESHNeoplasm Recurrence, Local/pathology*-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPancreatectomy*/adverse effects-
dc.subject.MESHPancreatectomy*/methods-
dc.subject.MESHPancreatic Neoplasms*/blood-
dc.subject.MESHPancreatic Neoplasms*/pathology-
dc.subject.MESHPancreatic Neoplasms*/therapy-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHTreatment Outcome-
dc.titlePathological Complete Remission of Pancreatic Cancer Following Neoadjuvant Chemoradiation Therapy; Not the End of Battles-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Surgery-
dc.contributor.googleauthorSung Hwan Lee-
dc.contributor.googleauthorChang Moo Kang-
dc.contributor.googleauthorHogeun Kim-
dc.contributor.googleauthorHo Kyoung Hwang-
dc.contributor.googleauthorSi Young Song-
dc.contributor.googleauthorJinsil Seong-
dc.contributor.googleauthorMyoung Jin Kim-
dc.contributor.googleauthorWoo Jung Lee-
dc.identifier.doi10.1097/MD.0000000000002168-
dc.contributor.localIdA00088-
dc.contributor.localIdA00426-
dc.contributor.localIdA01183-
dc.contributor.localIdA01956-
dc.contributor.localIdA02035-
dc.contributor.localIdA02875-
dc.contributor.localIdA02993-
dc.contributor.localIdA04497-
dc.relation.journalcodeJ02214-
dc.identifier.eissn1536-5964-
dc.identifier.pmid26717359-
dc.contributor.alternativeNameKang, Chang Moo-
dc.contributor.alternativeNameKim, Myeong Jin-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.alternativeNameSeong, Jin Sil-
dc.contributor.alternativeNameSong, Si Young-
dc.contributor.alternativeNameLee, Sung Hwan-
dc.contributor.alternativeNameLee, Woo Jung-
dc.contributor.alternativeNameHwang, Ho Kyoung-
dc.contributor.affiliatedAuthorKang, Chang Moo-
dc.contributor.affiliatedAuthorKim, Myeong Jin-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorSeong, Jin Sil-
dc.contributor.affiliatedAuthorSong, Si Young-
dc.contributor.affiliatedAuthorLee, Sung Hwan-
dc.contributor.affiliatedAuthorLee, Woo Jung-
dc.contributor.affiliatedAuthorHwang, Ho Kyoung-
dc.citation.volume94-
dc.citation.number52-
dc.citation.startPagee2168-
dc.identifier.bibliographicCitationMEDICINE, Vol.94(52) : e2168, 2015-
dc.identifier.rimsid41378-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.