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An inhibitory alternative splice isoform of Toll-like receptor 3 is induced by type I interferons in human astrocyte cell lines

DC FieldValueLanguage
dc.contributor.author김세훈-
dc.contributor.author서진원-
dc.contributor.author최인홍-
dc.date.accessioned2018-03-26T16:59:12Z-
dc.date.available2018-03-26T16:59:12Z-
dc.date.issued2015-
dc.identifier.issn1976-6696-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/157046-
dc.description.abstractToll-like receptor 3 (TLR3) recognizes viral double-stranded RNA. It stimulates pro-inflammatory cytokine and interferon production. Here we reported the expression of a novel isoform of TLR3 in human astrocyte cell lines whose message is generated by alternative splicing. The isoform represents the N-terminus of the protein. It lacks many of the leucine-rich repeat domains, the transmembrane domain, and the intracellular Toll/interferon-1 receptor domain of TLR3. Type I interferons (interferon-α and interferon-β) induced the expression of this isoform. Exogenous overexpression of this isoform inhibited interferon regulatory factor 3, signal transducers and activators of transcription 1, and Inhibitor of kappa Bα signaling following stimulation. This isoform of TLR3 also inhibited the production of chemokine interferon-γ-inducible protein 10. Our study clearly demonstrated that the expression of this isoform of TLR3 was a negative regulator of signaling pathways and that it was inducible by type I interferons. We also found that this isoform could modulate inflammation in the brain.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherKorean Society for Biochemistry and Molecular Biology-
dc.relation.isPartOfBMB Reports-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlternative Splicing-
dc.subject.MESHAstrocytes/drug effects-
dc.subject.MESHAstrocytes/immunology-
dc.subject.MESHAstrocytes/metabolism*-
dc.subject.MESHCell Line, Tumor-
dc.subject.MESHDown-Regulation-
dc.subject.MESHEncephalitis/genetics-
dc.subject.MESHEncephalitis/immunology-
dc.subject.MESHEncephalitis/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHInterferon Regulatory Factor-3/antagonists & inhibitors-
dc.subject.MESHInterferon Regulatory Factor-3/immunology-
dc.subject.MESHInterferon-alpha/immunology-
dc.subject.MESHInterferon-alpha/pharmacology*-
dc.subject.MESHInterferon-beta/immunology-
dc.subject.MESHInterferon-beta/pharmacology-
dc.subject.MESHPoly I-C/pharmacology-
dc.subject.MESHProtein Isoforms-
dc.subject.MESHRNA, Double-Stranded-
dc.subject.MESHSignal Transduction-
dc.subject.MESHToll-Like Receptor 3/biosynthesis*-
dc.subject.MESHToll-Like Receptor 3/genetics-
dc.subject.MESHToll-Like Receptor 3/immunology-
dc.titleAn inhibitory alternative splice isoform of Toll-like receptor 3 is induced by type I interferons in human astrocyte cell lines-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJin-Won Seo-
dc.contributor.googleauthorEun-Jeong Yang-
dc.contributor.googleauthorSe Hoon Kim-
dc.contributor.googleauthorIn-Hong Choi-
dc.identifier.doi10.5483/BMBRep.2015.48.12.106-
dc.contributor.localIdA00610-
dc.contributor.localIdA01918-
dc.contributor.localIdA04167-
dc.relation.journalcodeJ00348-
dc.identifier.eissn1976-670X-
dc.identifier.pmid26077030-
dc.subject.keywordAstrocyte-
dc.subject.keywordInterferon-
dc.subject.keywordIsoform-
dc.subject.keywordNegative regulation-
dc.subject.keywordTLR3-
dc.contributor.alternativeNameKim, Se Hoon-
dc.contributor.alternativeNameSeo, Jin Won-
dc.contributor.alternativeNameChoi, In Hong-
dc.contributor.affiliatedAuthorKim, Se Hoon-
dc.contributor.affiliatedAuthorSeo, Jin Won-
dc.contributor.affiliatedAuthorChoi, In Hong-
dc.citation.volume48-
dc.citation.number12-
dc.citation.startPage696-
dc.citation.endPage701-
dc.identifier.bibliographicCitationBMB Reports, Vol.48(12) : 696-701, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers

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