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Low Adherence to Immunosuppressants Is Associated With Symptom Experience Among Kidney Transplant Recipients

Authors
 S.Y. Lee  ;  S.H. Chu  ;  E.G. Oh  ;  K.H. Huh 
Citation
 TRANSPLANTATION PROCEEDINGS, Vol.47(9) : 2707-2711, 2015 
Journal Title
 TRANSPLANTATION PROCEEDINGS 
ISSN
 0041-1345 
Issue Date
2015
MeSH
Adult ; Fatigue/psychology ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents/therapeutic use* ; Kidney Transplantation/psychology* ; Male ; Medication Adherence/statistics & numerical data* ; Middle Aged ; Postoperative Complications/prevention & control ; Postoperative Complications/psychology* ; Quality of Life ; Self Report ; Time Factors ; Transplant Recipients/psychology*
Abstract
PURPOSE: The purpose of this study was to investigate the relationship between immunosuppressant-related symptom experience (SE) and adherence to immunosuppressant regimens among kidney transplant (KT) recipients. METHODS: A total of 239 KT recipients on an immunosuppressant regimen who were followed up after transplantation participated in this study. Data was collected through a self-reported questionnaire survey (medication adherence, SE, and quality of life) and medical record review. RESULTS: Low adherence in the immunosuppressant group was associated with longer time since KT, less comorbidity (<3), and a higher rehospitalization rate. Low adherence among KT recipients showed significantly greater overall symptom occurrence (P = .001) and symptom distress (P = .002) levels than patients with high or medium adherence after adjusting for a number of covariates. The most common symptom both in terms of occurrence (96.4%) and distress (91.1%) among poorly adherent KT recipients was tiredness. CONCLUSION: Low adherence to an immunosuppressant regimen was significantly associated with high SE among KT recipients. Strategies to decrease immunosuppressant-related SE are needed to improve adherence to immunosuppressants.
Full Text
http://www.sciencedirect.com/science/article/pii/S0041134515009239
DOI
10.1016/j.transproceed.2015.09.056
Appears in Collections:
3. College of Nursing (간호대학) > Dept. of Nursing (간호학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Oh, Eui Geum(오의금) ORCID logo https://orcid.org/0000-0002-6941-0708
Chu, Sang Hui(추상희) ORCID logo https://orcid.org/0000-0001-6877-5599
Huh, Kyu Ha(허규하) ORCID logo https://orcid.org/0000-0003-1364-6989
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/157006
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