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Risk Factors for Rickets of Prematurity in Extremely Low Birth Weight Infants

Authors
 Yun Jung Choi  ;  Soon Min Lee  ;  Jeong Eun Shin  ;  Ho Seon Eun  ;  Min Soo Park  ;  Kook In Park  ;  Ran Namgung 
Citation
 Neonatal Medicine, Vol.22(4) : 192-197, 2015 
Journal Title
 Neonatal Medicine 
ISSN
 2287-9412 
Issue Date
2015
Keywords
Infants ; Premature ; Extremely low birth weight ; Rickets ; Risk factors ; Enteral nutrition ; Body weight change
Abstract
Purpose : This study aimed to analyze the risk factors for the development of rickets of prematurity in extremely low birth weight (ELBW) infants. Methods : We retrospectively reviewed the data of 57 ELBW infants. Nineteen infants were diagnosed with rickets and 38 infants without rickets were recruited. On radiologic evaluation, 47% of infants had grade I, 37% had grade II, and 16% had grade III rickets. Results : In ELBW infants with rickets, the durations of oxygen administration, mechanical ventilation, parenteral nutrition, and hospitalization were significantly longer compared to those of the control group. The number of days for achieving an enteral caloric intake of 80 kcal/kg/d and the number of days for regaining birth weight were significantly longer compared to those of the control group. Serial weight changes from birth weight during 8 weeks after birth was significantly lower in the rickets group than in the control group. Retinopathy of prematurity was significantly higher in the rickets group than in the control group. After adjustment for birth weight, rickets of prematurity was correlated with days for regaining birth weight (odds ratio [OR], 1.316; P=0.010), and with weight changes from birth weight at 4 weeks of age (OR, 0.964; P=0.033). Conclusion : In ELBW infants, the risk factors for rickets of prematurity were days for regaining birth weight from birth and the weight changes at 4 weeks of age. Early aggressive nutrition for regaining birth weight earlier may reduce the development of rickets of prematurity.
Files in This Item:
T201504994.pdf Download
DOI
10.5385/nm.2015.22.4.192
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Namgung, Ran(남궁란) ORCID logo https://orcid.org/0000-0001-7182-9535
Park, Kook In(박국인) ORCID logo https://orcid.org/0000-0001-8499-9293
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Shin, Jeong Eun(신정은) ORCID logo https://orcid.org/0000-0002-4376-8541
Eun, Ho Seon(은호선) ORCID logo https://orcid.org/0000-0001-7212-0341
Lee, Soon Min(이순민) ORCID logo https://orcid.org/0000-0003-0174-1065
Choi, Yun Jung(최윤정)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156978
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