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Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

Authors
 Byeong Mo Kim  ;  Yunkyung Hong  ;  Seunghoon Lee  ;  Pengda Liu  ;  Ji Hong Lim  ;  Yong Heon Lee  ;  Tae Ho Lee  ;  Kyu Tae Chang  ;  Yonggeun Hong 
Citation
 International Journal of Molecular Sciences, Vol.16(11) : 26880-26913, 2015 
Journal Title
 International Journal of Molecular Sciences 
Issue Date
2015
MeSH
Apoptosis/genetics ; Apoptosis/radiation effects ; Autophagy/genetics ; Autophagy/radiation effects ; Chromosome Aberrations* ; Combined Modality Therapy/methods* ; Cytogenetic Analysis ; DNA Damage/radiation effects ; Gamma Rays/therapeutic use* ; Genomic Instability ; Humans ; Mitosis/radiation effects ; Necrosis/genetics ; Necrosis/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy* ; Radiation Tolerance/drug effects* ; Radiation-Sensitizing Agents/therapeutic use* ; X-Ray Therapy
Keywords
DNA damage ; cancer therapy ; cell death ; ionizing radiation (IR) ; prognostic markers ; resistance ; therapeutic targets
Abstract
Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence. Among them, apoptosis and mitotic catastrophe are the main mechanisms of IR action. DNA damage and genomic instability contribute to IR-induced cancer cell death. Although IR therapy may be curative in a number of cancer types, the resistance of cancer cells to radiation remains a major therapeutic problem. In this review, we describe the morphological and molecular aspects of various IR-induced types of cell death. We also discuss cytogenetic variations representative of IR-induced DNA damage and genomic instability. Most importantly, we focus on several pathways and their associated marker proteins responsible for cancer resistance and its therapeutic implications in terms of cancer cell death of various types and characteristics. Finally, we propose radiation-sensitization strategies, such as the modification of fractionation, inflammation, and hypoxia and the combined treatment, that can counteract the resistance of tumors to IR.
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156939
DOI
10.3390/ijms161125991
Appears in Collections:
1. Journal Papers (연구논문) > 5. Research Institutes (연구소) > Yonsei Integrative Research Institute for Cerebral & Cardiovascular Disease (뇌심혈관질환융합연구사업단)
Yonsei Authors
김병모(Kim, Byeong Mo)
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