Cited 180 times in

Therapeutic Implications for Overcoming Radiation Resistance in Cancer Therapy

Authors
 Byeong Mo Kim  ;  Yunkyung Hong  ;  Seunghoon Lee  ;  Pengda Liu  ;  Ji Hong Lim  ;  Yong Heon Lee  ;  Tae Ho Lee  ;  Kyu Tae Chang  ;  Yonggeun Hong 
Citation
 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, Vol.16(11) : 26880-26913, 2015 
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
 1661-6596 
Issue Date
2015
MeSH
Apoptosis/genetics ; Apoptosis/radiation effects ; Autophagy/genetics ; Autophagy/radiation effects ; Chromosome Aberrations* ; Combined Modality Therapy/methods* ; Cytogenetic Analysis ; DNA Damage/radiation effects ; Gamma Rays/therapeutic use* ; Genomic Instability ; Humans ; Mitosis/radiation effects ; Necrosis/genetics ; Necrosis/pathology ; Neoplasms/genetics ; Neoplasms/pathology ; Neoplasms/therapy* ; Radiation Tolerance/drug effects* ; Radiation-Sensitizing Agents/therapeutic use* ; X-Ray Therapy
Keywords
DNA damage ; cancer therapy ; cell death ; ionizing radiation (IR) ; prognostic markers ; resistance ; therapeutic targets
Abstract
Ionizing radiation (IR), such as X-rays and gamma (γ)-rays, mediates various forms of cancer cell death such as apoptosis, necrosis, autophagy, mitotic catastrophe, and senescence. Among them, apoptosis and mitotic catastrophe are the main mechanisms of IR action. DNA damage and genomic instability contribute to IR-induced cancer cell death. Although IR therapy may be curative in a number of cancer types, the resistance of cancer cells to radiation remains a major therapeutic problem. In this review, we describe the morphological and molecular aspects of various IR-induced types of cell death. We also discuss cytogenetic variations representative of IR-induced DNA damage and genomic instability. Most importantly, we focus on several pathways and their associated marker proteins responsible for cancer resistance and its therapeutic implications in terms of cancer cell death of various types and characteristics. Finally, we propose radiation-sensitization strategies, such as the modification of fractionation, inflammation, and hypoxia and the combined treatment, that can counteract the resistance of tumors to IR.
Files in This Item:
T201504950.pdf Download
DOI
10.3390/ijms161125991
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Kim, Byeong Mo(김병모) ORCID logo https://orcid.org/0000-0002-0582-3132
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156939
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links