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IL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse model

 Ju Young Choi  ;  Bunsoon Choi  ;  Ju A. Shim  ;  Eun-So Lee  ;  Do Young Kim  ;  Dongsik Bang  ;  Seonghyang Sohn 
 IMMUNOBIOLOGY, Vol.220(12) : 1381-1392, 2015 
Journal Title
Issue Date
Adult ; Animals ; Antibodies, Monoclonal/administration & dosage ; Antibodies, Monoclonal/immunology* ; Antigen-Antibody Complex/immunology* ; Behcet Syndrome/drug therapy ; Behcet Syndrome/immunology* ; Behcet Syndrome/metabolism* ; Behcet Syndrome/virology ; Case-Control Studies ; Disease Models, Animal ; Etanercept/pharmacology ; Etanercept/therapeutic use ; Female ; Humans ; Immunologic Memory ; Immunophenotyping ; Immunosuppressive Agents/pharmacology ; Immunosuppressive Agents/therapeutic use ; Interleukin Receptor Common gamma Subunit/metabolism ; Interleukin-2/blood ; Interleukin-2/immunology* ; Interleukin-2 Receptor alpha Subunit/metabolism ; Interleukin-2 Receptor beta Subunit/antagonists & inhibitors ; Interleukin-2 Receptor beta Subunit/metabolism ; Killer Cells, Natural/immunology ; Killer Cells, Natural/metabolism ; Leukocytes, Mononuclear/immunology ; Leukocytes, Mononuclear/metabolism ; Lymphocyte Count ; Male ; Mice ; Middle Aged ; Receptors, Interleukin-2/metabolism* ; Simplexvirus* ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Up-Regulation ; Young Adult
IL-2/IL-2 antibody immune complex ; Behçet’s disease ; Mouse model ; HSV ; IL-2Rαβγ
The differences of serum IL-2 levels were not consistent between Behçet's Disease (BD) patients and healthy controls, however, the correlation of interleukin-2 receptor (IL-2R) and BD has not been investigated. IL-2R is composed of three subunits; alpha, beta, and gamma. The expression frequencies of IL-2R subunits were analyzed in the peripheral blood mononuclear cells, spleens, and lymph node (LN) cells. The expression of IL-2R subunits was different between BD mice and controls. IL-2R beta expressing cell frequencies were also different between BD patients and healthy controls. The IL-2/anti-mIL-2 antibody complex administration regulated the IL-2R subunits in mice. The change of expression in IL-2R was accompanied by the increase of CD8+CD44+ memory T cells, CD3-NK1.1+CD11b+CD27+ natural killer cells, and improvement of symptoms. In this study, we elucidated the role of IL-2R subunits on BD, a finding that can be connected to therapeutic strategy for patients based on the results from the treatment of BD mice.
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1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영) ORCID logo https://orcid.org/0000-0002-0194-9854
Bang, Dong Sik(방동식)
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