Cited 7 times in
IL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse model
DC Field | Value | Language |
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dc.contributor.author | 김도영 | - |
dc.contributor.author | 방동식 | - |
dc.date.accessioned | 2018-03-26T16:53:17Z | - |
dc.date.available | 2018-03-26T16:53:17Z | - |
dc.date.issued | 2015 | - |
dc.identifier.issn | 0171-2985 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156921 | - |
dc.description.abstract | The differences of serum IL-2 levels were not consistent between Behçet's Disease (BD) patients and healthy controls, however, the correlation of interleukin-2 receptor (IL-2R) and BD has not been investigated. IL-2R is composed of three subunits; alpha, beta, and gamma. The expression frequencies of IL-2R subunits were analyzed in the peripheral blood mononuclear cells, spleens, and lymph node (LN) cells. The expression of IL-2R subunits was different between BD mice and controls. IL-2R beta expressing cell frequencies were also different between BD patients and healthy controls. The IL-2/anti-mIL-2 antibody complex administration regulated the IL-2R subunits in mice. The change of expression in IL-2R was accompanied by the increase of CD8+CD44+ memory T cells, CD3-NK1.1+CD11b+CD27+ natural killer cells, and improvement of symptoms. In this study, we elucidated the role of IL-2R subunits on BD, a finding that can be connected to therapeutic strategy for patients based on the results from the treatment of BD mice. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Elsevier | - |
dc.relation.isPartOf | IMMUNOBIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antibodies, Monoclonal/administration & dosage | - |
dc.subject.MESH | Antibodies, Monoclonal/immunology* | - |
dc.subject.MESH | Antigen-Antibody Complex/immunology* | - |
dc.subject.MESH | Behcet Syndrome/drug therapy | - |
dc.subject.MESH | Behcet Syndrome/immunology* | - |
dc.subject.MESH | Behcet Syndrome/metabolism* | - |
dc.subject.MESH | Behcet Syndrome/virology | - |
dc.subject.MESH | Case-Control Studies | - |
dc.subject.MESH | Disease Models, Animal | - |
dc.subject.MESH | Etanercept/pharmacology | - |
dc.subject.MESH | Etanercept/therapeutic use | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Immunologic Memory | - |
dc.subject.MESH | Immunophenotyping | - |
dc.subject.MESH | Immunosuppressive Agents/pharmacology | - |
dc.subject.MESH | Immunosuppressive Agents/therapeutic use | - |
dc.subject.MESH | Interleukin Receptor Common gamma Subunit/metabolism | - |
dc.subject.MESH | Interleukin-2/blood | - |
dc.subject.MESH | Interleukin-2/immunology* | - |
dc.subject.MESH | Interleukin-2 Receptor alpha Subunit/metabolism | - |
dc.subject.MESH | Interleukin-2 Receptor beta Subunit/antagonists & inhibitors | - |
dc.subject.MESH | Interleukin-2 Receptor beta Subunit/metabolism | - |
dc.subject.MESH | Killer Cells, Natural/immunology | - |
dc.subject.MESH | Killer Cells, Natural/metabolism | - |
dc.subject.MESH | Leukocytes, Mononuclear/immunology | - |
dc.subject.MESH | Leukocytes, Mononuclear/metabolism | - |
dc.subject.MESH | Lymphocyte Count | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Receptors, Interleukin-2/metabolism* | - |
dc.subject.MESH | Simplexvirus* | - |
dc.subject.MESH | T-Lymphocytes/drug effects | - |
dc.subject.MESH | T-Lymphocytes/immunology | - |
dc.subject.MESH | T-Lymphocytes/metabolism | - |
dc.subject.MESH | Up-Regulation | - |
dc.subject.MESH | Young Adult | - |
dc.title | IL-2/IL-2 antibody immune complex regulates HSV-induced inflammation through induction of IL-2 receptor alpha, beta, and gamma in a mouse model | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Dermatology | - |
dc.contributor.googleauthor | Ju Young Choi | - |
dc.contributor.googleauthor | Bunsoon Choi | - |
dc.contributor.googleauthor | Ju A. Shim | - |
dc.contributor.googleauthor | Eun-So Lee | - |
dc.contributor.googleauthor | Do Young Kim | - |
dc.contributor.googleauthor | Dongsik Bang | - |
dc.contributor.googleauthor | Seonghyang Sohn | - |
dc.identifier.doi | 10.1016/j.imbio.2015.07.004 | - |
dc.contributor.localId | A00384 | - |
dc.contributor.localId | A01784 | - |
dc.relation.journalcode | J01035 | - |
dc.identifier.eissn | 1878-3279 | - |
dc.identifier.pmid | 26213097 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0171298515300243 | - |
dc.subject.keyword | IL-2/IL-2 antibody immune complex | - |
dc.subject.keyword | Behçet’s disease | - |
dc.subject.keyword | Mouse model | - |
dc.subject.keyword | HSV | - |
dc.subject.keyword | IL-2Rαβγ | - |
dc.contributor.alternativeName | Kim, Do Young | - |
dc.contributor.alternativeName | Bang, Dong Sik | - |
dc.contributor.affiliatedAuthor | Kim, Do Young | - |
dc.contributor.affiliatedAuthor | Bang, Dong Sik | - |
dc.citation.volume | 220 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1381 | - |
dc.citation.endPage | 1392 | - |
dc.identifier.bibliographicCitation | IMMUNOBIOLOGY, Vol.220(12) : 1381-1392, 2015 | - |
dc.identifier.rimsid | 41230 | - |
dc.type.rims | ART | - |
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