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The neural basis of a deficit in abstract thinking in patients with schizophrenia

Authors
 Jooyoung Oh  ;  Ji-Won Chun  ;  Hang Joon Jo  ;  Eunseong Kim  ;  Hae-Jeong Park  ;  Boreom Lee  ;  Jae-Jin Kim 
Citation
 PSYCHIATRY RESEARCH-NEUROIMAGING, Vol.234(1) : 66-73, 2015 
Journal Title
 PSYCHIATRY RESEARCH-NEUROIMAGING 
ISSN
 0925-4927 
Issue Date
2015
MeSH
Adult ; Brain/physiopathology* ; Brain Mapping ; Emotions/physiology ; Female ; Humans ; Magnetic Resonance Imaging/methods ; Male ; Neuropsychological Tests ; Schizophrenia/physiopathology* ; Schizophrenic Psychology* ; Social Behavior ; Thinking/physiology* ; Young Adult
Keywords
Abstract thinking ; FMRI ; Frontopolar cortex ; Orbitofrontal cortex ; Schizophrenia ; Theme identification
Abstract
Abnormal abstract thinking is a major cause of social dysfunction in patients with schizophrenia, but little is known about its neural basis. In this study, we aimed to determine the characteristic abstract thinking-related brain responses in patients using a task reflecting social situations. We conducted functional magnetic resonance imaging while 16 patients with schizophrenia and 16 healthy controls performed a theme-identification task, in which various emotional pictures depicting social situations were presented. Compared with healthy controls, the patients showed significantly decreased activity in the left frontopolar and right orbitofrontal cortices during theme identification. Activity in these two regions correlated well in the controls, but not in patients. Instead, the patients exhibited a close correlation between activity in both sides of the frontopolar cortex, and a positive correlation between the right orbitofrontal cortex activity and degrees of theme identification. Reduced activity in the left frontopolar and right orbitofrontal cortices and the underlying aberrant connectivity may be implicated in the patients' deficits in abstract thinking. These newly identified features of the neural basis of abnormal abstract thinking are important as they have implications for the impaired social behavior of patients with schizophrenia during real-life situations.
Full Text
http://www.sciencedirect.com/science/article/pii/S0925492715300615
DOI
10.1016/j.pscychresns.2015.08.007
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
Park, Hae Jeong(박해정) ORCID logo https://orcid.org/0000-0002-4633-0756
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156820
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