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Specific Immunotherapy in Atopic Dermatitis

Authors
 Jungsoo Lee  ;  Chang Ook Park  ;  Kwang Hoon Lee 
Citation
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH, Vol.7(3) : 221-229, 2015 
Journal Title
 ALLERGY ASTHMA & IMMUNOLOGY RESEARCH 
ISSN
 2092-7355 
Issue Date
2015
Keywords
Specific immunotherapy ; atopic dermatitis ; biomarker ; clinical efficacy ; subcutaneous immunotherapy
Abstract
Allergen specific immunotherapy (SIT) using house dust mite (HDM) extracts has been performed mainly with patients of asthma and allergic rhinitis. In the meanwhile, there has been a long debate on the efficacy of SIT in atopic dermatitis (AD) with only a few double-blind placebo-controlled trials. However, several randomized controlled trials of SIT in AD revealed significant improvement of clinical symptoms and also, positive result was shown by a following meta-analysis study of these trials. In order to predict and evaluate the treatment outcome, finding a biomarker that can predict treatment responses and treatment end-points is critical but it is very challenging at the same time due to the complexity of causes and mechanisms of AD. Other considerations including standardization of the easiest and safest treatment protocol and optimizing the treatment preparations should be studied as well. This review summarizes the basics of SIT in AD including the brief mechanisms, treatment methods and schedules, and also highlights the clinical efficacy of SIT in AD along with mild, controllable adverse reactions. Immunologic effects and studies of various biomarkers are also introduced and finally, future considerations with upcoming studies on SIT were discussed.
Files in This Item:
T201504698.pdf Download
DOI
10.4168/aair.2015.7.3.221
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Park, Chang Ook(박창욱) ORCID logo https://orcid.org/0000-0003-3856-1201
Lee, Kwang Hoon(이광훈)
Lee, Jungsoo(이정수)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156799
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