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Expression of Yes-associated protein (YAP) in metastatic breast cancer.

 Hye Min Kim  ;  Woo Hee Jung  ;  Ja Seung Koo 
 International Journal of Clinical and Experimental Pathology, Vol.8(9) : 11248-11257, 2015 
Journal Title
 International Journal of Clinical and Experimental Pathology 
Issue Date
Adaptor Proteins, Signal Transducing/analysis* ; Biomarkers, Tumor/analysis* ; Bone Neoplasms/chemistry* ; Bone Neoplasms/mortality ; Bone Neoplasms/secondary ; Bone Neoplasms/therapy ; Brain Neoplasms/chemistry* ; Brain Neoplasms/mortality ; Brain Neoplasms/secondary ; Brain Neoplasms/therapy ; Breast Neoplasms/chemistry* ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Cell Nucleus/chemistry ; Female ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Liver Neoplasms/chemistry* ; Liver Neoplasms/mortality ; Liver Neoplasms/secondary ; Liver Neoplasms/therapy ; Lung Neoplasms/chemistry* ; Lung Neoplasms/mortality ; Lung Neoplasms/secondary ; Lung Neoplasms/therapy ; Middle Aged ; Phosphoproteins/analysis* ; Phosphorylation ; Risk Factors ; Time Factors ; Tissue Array Analysis ; Treatment Outcome ; Up-Regulation
Breast cancer ; YAP ; metastasis
The purpose of this study was to investigate the expression of Yes-associated protein (YAP) in different metastatic sites in metastatic breast cancer and to determine the clinical implications of these patterns. Immunohistochemical staining was used to investigate the expression of YAP and phospho-YAP in tissue microarrays from 122 cases of metastatic breast cancer (bone metastasis = 29, brain metastasis = 38, liver metastasis = 12, and lung metastasis = 43). The expression levels of YAP and phospho-YAP differed according to the metastatic site in metastatic breast cancer. Specifically, nuclear expression of phospho-YAP was high in brain metastasis but low in lung metastasis (P = 0.010). The effects of YAP and phospho-YAP expression on clinical outcomes were investigated by univariate analysis. This analysis showed that nuclear YAP positivity (P = 0.008) and nuclear phospho-YAP positivity (P = 0.003) were both associated with shorter overall survival. In conclusion, the level of YAP expression varies according to the metastatic site in metastatic breast cancer. Moreover, high YAP expression was correlated with poor prognosis.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Koo, Ja Seung(구자승) ORCID logo https://orcid.org/0000-0003-4546-4709
Kim, Hye Min(김혜민) ORCID logo https://orcid.org/0000-0002-2899-9480
Jung, Woo Hee(정우희)
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