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Expression of Yes-associated protein (YAP) in metastatic breast cancer.

DC Field Value Language
dc.contributor.author구자승-
dc.contributor.author김혜민-
dc.contributor.author정우희-
dc.date.accessioned2018-03-26T16:45:33Z-
dc.date.available2018-03-26T16:45:33Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156790-
dc.description.abstractThe purpose of this study was to investigate the expression of Yes-associated protein (YAP) in different metastatic sites in metastatic breast cancer and to determine the clinical implications of these patterns. Immunohistochemical staining was used to investigate the expression of YAP and phospho-YAP in tissue microarrays from 122 cases of metastatic breast cancer (bone metastasis = 29, brain metastasis = 38, liver metastasis = 12, and lung metastasis = 43). The expression levels of YAP and phospho-YAP differed according to the metastatic site in metastatic breast cancer. Specifically, nuclear expression of phospho-YAP was high in brain metastasis but low in lung metastasis (P = 0.010). The effects of YAP and phospho-YAP expression on clinical outcomes were investigated by univariate analysis. This analysis showed that nuclear YAP positivity (P = 0.008) and nuclear phospho-YAP positivity (P = 0.003) were both associated with shorter overall survival. In conclusion, the level of YAP expression varies according to the metastatic site in metastatic breast cancer. Moreover, high YAP expression was correlated with poor prognosis.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publishere-Century Pub. Corp.-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdaptor Proteins, Signal Transducing/analysis*-
dc.subject.MESHBiomarkers, Tumor/analysis*-
dc.subject.MESHBone Neoplasms/chemistry*-
dc.subject.MESHBone Neoplasms/mortality-
dc.subject.MESHBone Neoplasms/secondary-
dc.subject.MESHBone Neoplasms/therapy-
dc.subject.MESHBrain Neoplasms/chemistry*-
dc.subject.MESHBrain Neoplasms/mortality-
dc.subject.MESHBrain Neoplasms/secondary-
dc.subject.MESHBrain Neoplasms/therapy-
dc.subject.MESHBreast Neoplasms/chemistry*-
dc.subject.MESHBreast Neoplasms/mortality-
dc.subject.MESHBreast Neoplasms/pathology-
dc.subject.MESHBreast Neoplasms/therapy-
dc.subject.MESHCell Nucleus/chemistry-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver Neoplasms/chemistry*-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/secondary-
dc.subject.MESHLiver Neoplasms/therapy-
dc.subject.MESHLung Neoplasms/chemistry*-
dc.subject.MESHLung Neoplasms/mortality-
dc.subject.MESHLung Neoplasms/secondary-
dc.subject.MESHLung Neoplasms/therapy-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPhosphoproteins/analysis*-
dc.subject.MESHPhosphorylation-
dc.subject.MESHRisk Factors-
dc.subject.MESHTime Factors-
dc.subject.MESHTissue Array Analysis-
dc.subject.MESHTreatment Outcome-
dc.subject.MESHUp-Regulation-
dc.titleExpression of Yes-associated protein (YAP) in metastatic breast cancer.-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorHye Min Kim-
dc.contributor.googleauthorWoo Hee Jung-
dc.contributor.googleauthorJa Seung Koo-
dc.identifier.doi2015-
dc.contributor.localIdA00198-
dc.contributor.localIdA04553-
dc.contributor.localIdA03671-
dc.relation.journalcodeJ01096-
dc.identifier.eissn1936-2625-
dc.identifier.pmid26617849-
dc.subject.keywordBreast cancer-
dc.subject.keywordYAP-
dc.subject.keywordmetastasis-
dc.contributor.alternativeNameKoo, Ja Seung-
dc.contributor.alternativeNameKim, Hye Min-
dc.contributor.alternativeNameJung, Woo Hee-
dc.contributor.affiliatedAuthorKoo, Ja Seung-
dc.contributor.affiliatedAuthorKim, Hye Min-
dc.contributor.affiliatedAuthorJung, Woo Hee-
dc.contributor.affiliatedAuthor구자승-
dc.citation.volume8-
dc.citation.number9-
dc.citation.startPage11248-
dc.citation.endPage11257-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, Vol.8(9) : 11248-11257, 2015-
dc.identifier.rimsid39918-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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