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Comparison of computed tomography findings between renal oncocytomas and chromophobe renal cell carcinomas

 Jae Hyeok Choi  ;  Jong Won Kim  ;  Joo Yong Lee  ;  Woong Kyu Han  ;  Koon Ho Rha  ;  Young Deuk Choi  ;  Sung Joon Hong  ;  Young Eun Yoon 
 KOREAN JOURNAL OF UROLOGY, Vol.56(10) : 695-702, 2015 
Journal Title
Issue Date
Adenoma, Oxyphilic/diagnostic imaging* ; Adenoma, Oxyphilic/pathology ; Carcinoma, Renal Cell/diagnostic imaging* ; Carcinoma, Renal Cell/pathology ; Diagnosis, Differential ; Female ; Humans ; Kidney Neoplasms/diagnostic imaging* ; Kidney Neoplasms/pathology ; Male ; Middle Aged ; Retrospective Studies ; Tomography, X-Ray Computed
Renal cell carcinoma ; Renal oncocytoma ; X-ray computed tomography
PURPOSE: To investigate and distinguish the computed tomography (CT) characteristics of chromophobe renal cell carcinoma (chRCC) and renal oncocytoma. MATERIALS AND METHODS: Fifty-one patients with renal oncocytoma and 120 patients with chRCC, diagnosed by surgery between November 2005 and June 2015, were studied retrospectively. Two observers, who were urologists and unaware of the pathological results, reviewed the preoperative CT images. The tumors were evaluated for size, laterality, tumor type (ball or bean pattern), central stellate scar, segmental enhancement inversion, and angular interface pattern and tumor complexity. To accurately analyze the mass-enhancing pattern of renal mass, we measured Hounsfield units (HUs) in each phase and analyzed the mean, maximum, and minimum HU values and standard deviations. RESULTS: There were 51 renal oncocytomas and 120 chRCCs in the study cohort. No differences in clinical and demographic characteristics were observed between the two groups. A central stellate scar and segmental enhancement inversion were more likely in oncocytomas. However, there were no differences in ball-/bean-type categorization, enhancement pattern, and the shape of the interface between the groups. Higher HU values tended to be present in the corticomedullary and nephrogenic phases in oncocytomas than in chRCC. Receiver-operating characteristic curve analysis showed that the presence of a central stellate scar and higher mean HU values in the nephrogenic phase were highly predictive of renal oncocytoma (area under the curve=0.817, p<0.001). CONCLUSIONS: The appearance of a central stellate scar and higher mean HU values in the nephrogenic phase could be useful to distinguish renal oncocytomas from chRCCs.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jong Won(김종원) ORCID logo https://orcid.org/0000-0002-0449-228X
Rha, Koon Ho(나군호) ORCID logo https://orcid.org/0000-0001-8588-7584
Yoon, Young Eun(윤영은)
Lee, Joo Yong(이주용) ORCID logo https://orcid.org/0000-0002-3470-1767
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
Choi, Jae Hyeok(최재혁)
Han, Woong Kyu(한웅규) ORCID logo https://orcid.org/0000-0002-2527-4046
Hong, Sung Joon(홍성준) ORCID logo https://orcid.org/0000-0001-9869-065X
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