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The full repertoire of Drosophila gustatory receptors for detecting an aversive compound

DC Field Value Language
dc.contributor.author김연정-
dc.contributor.author문석준-
dc.contributor.author이민구-
dc.contributor.author정용택-
dc.date.accessioned2018-03-26T16:42:54Z-
dc.date.available2018-03-26T16:42:54Z-
dc.date.issued2015-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156745-
dc.description.abstractThe ability to detect toxic compounds in foods is essential for animal survival. However, the minimal subunit composition of gustatory receptors required for sensing aversive chemicals in Drosophila is unknown. Here we report that three gustatory receptors, GR8a, GR66a and GR98b function together in the detection of L-canavanine, a plant-derived insecticide. Ectopic co-expression of Gr8a and Gr98b in Gr66a-expressing, bitter-sensing gustatory receptor neurons (GRNs) confers responsiveness to L-canavanine. Furthermore, misexpression of all three Grs enables salt- or sweet-sensing GRNs to respond to L-canavanine. Introduction of these Grs in sweet-sensing GRNs switches L-canavanine from an aversive to an attractive compound. Co-expression of GR8a, GR66a and GR98b in Drosophila S2 cells induces an L-canavanine-activated nonselective cation conductance. We conclude that three GRs collaborate to produce a functional L-canavanine receptor. Thus, our results clarify the full set of GRs underlying the detection of a toxic tastant that drives avoidance behaviour in an insect.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherNature Pub. Group-
dc.relation.isPartOfNATURE COMMUNICATIONS-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHAvoidance Learning*-
dc.subject.MESHCanavanine/metabolism*-
dc.subject.MESHChemoreceptor Cells/metabolism-
dc.subject.MESHDrosophila Proteins/genetics-
dc.subject.MESHDrosophila Proteins/metabolism*-
dc.subject.MESHDrosophila melanogaster-
dc.subject.MESHInsecticides/metabolism*-
dc.subject.MESHPatch-Clamp Techniques-
dc.subject.MESHReceptors, Cell Surface/genetics-
dc.subject.MESHReceptors, Cell Surface/metabolism*-
dc.subject.MESHTaste Buds/metabolism*-
dc.titleThe full repertoire of Drosophila gustatory receptors for detecting an aversive compound-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pharmacology-
dc.contributor.googleauthorJaewon Shim-
dc.contributor.googleauthorYoungseok Lee-
dc.contributor.googleauthorYong Taek Jeong-
dc.contributor.googleauthorYonjung Kim-
dc.contributor.googleauthorMin Goo Lee-
dc.contributor.googleauthorCraig Montell-
dc.contributor.googleauthorSeok Jun Moon-
dc.identifier.doi10.1038/ncomms9867-
dc.contributor.localIdA00695-
dc.contributor.localIdA01358-
dc.contributor.localIdA02781-
dc.contributor.localIdA03663-
dc.relation.journalcodeJ02293-
dc.identifier.eissn2041-1723-
dc.identifier.pmid26568264-
dc.contributor.alternativeNameKim, Yon Jung-
dc.contributor.alternativeNameMoon, Seok Jun-
dc.contributor.alternativeNameLee, Min Goo-
dc.contributor.alternativeNameJeong, Yong Taek-
dc.contributor.affiliatedAuthorKim, Yon Jung-
dc.contributor.affiliatedAuthorMoon, Seok Jun-
dc.contributor.affiliatedAuthorLee, Min Goo-
dc.contributor.affiliatedAuthorJeong, Yong Taek-
dc.citation.volume6-
dc.citation.startPage8867-
dc.identifier.bibliographicCitationNATURE COMMUNICATIONS, Vol.6 : 8867, 2015-
dc.identifier.rimsid39874-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pharmacology (약리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers

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