Cited 85 times in
The full repertoire of Drosophila gustatory receptors for detecting an aversive compound
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김연정 | - |
dc.contributor.author | 문석준 | - |
dc.contributor.author | 이민구 | - |
dc.contributor.author | 정용택 | - |
dc.date.accessioned | 2018-03-26T16:42:54Z | - |
dc.date.available | 2018-03-26T16:42:54Z | - |
dc.date.issued | 2015 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/156745 | - |
dc.description.abstract | The ability to detect toxic compounds in foods is essential for animal survival. However, the minimal subunit composition of gustatory receptors required for sensing aversive chemicals in Drosophila is unknown. Here we report that three gustatory receptors, GR8a, GR66a and GR98b function together in the detection of L-canavanine, a plant-derived insecticide. Ectopic co-expression of Gr8a and Gr98b in Gr66a-expressing, bitter-sensing gustatory receptor neurons (GRNs) confers responsiveness to L-canavanine. Furthermore, misexpression of all three Grs enables salt- or sweet-sensing GRNs to respond to L-canavanine. Introduction of these Grs in sweet-sensing GRNs switches L-canavanine from an aversive to an attractive compound. Co-expression of GR8a, GR66a and GR98b in Drosophila S2 cells induces an L-canavanine-activated nonselective cation conductance. We conclude that three GRs collaborate to produce a functional L-canavanine receptor. Thus, our results clarify the full set of GRs underlying the detection of a toxic tastant that drives avoidance behaviour in an insect. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Nature Pub. Group | - |
dc.relation.isPartOf | NATURE COMMUNICATIONS | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Avoidance Learning* | - |
dc.subject.MESH | Canavanine/metabolism* | - |
dc.subject.MESH | Chemoreceptor Cells/metabolism | - |
dc.subject.MESH | Drosophila Proteins/genetics | - |
dc.subject.MESH | Drosophila Proteins/metabolism* | - |
dc.subject.MESH | Drosophila melanogaster | - |
dc.subject.MESH | Insecticides/metabolism* | - |
dc.subject.MESH | Patch-Clamp Techniques | - |
dc.subject.MESH | Receptors, Cell Surface/genetics | - |
dc.subject.MESH | Receptors, Cell Surface/metabolism* | - |
dc.subject.MESH | Taste Buds/metabolism* | - |
dc.title | The full repertoire of Drosophila gustatory receptors for detecting an aversive compound | - |
dc.type | Article | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pharmacology | - |
dc.contributor.googleauthor | Jaewon Shim | - |
dc.contributor.googleauthor | Youngseok Lee | - |
dc.contributor.googleauthor | Yong Taek Jeong | - |
dc.contributor.googleauthor | Yonjung Kim | - |
dc.contributor.googleauthor | Min Goo Lee | - |
dc.contributor.googleauthor | Craig Montell | - |
dc.contributor.googleauthor | Seok Jun Moon | - |
dc.identifier.doi | 10.1038/ncomms9867 | - |
dc.contributor.localId | A00695 | - |
dc.contributor.localId | A01358 | - |
dc.contributor.localId | A02781 | - |
dc.contributor.localId | A03663 | - |
dc.relation.journalcode | J02293 | - |
dc.identifier.eissn | 2041-1723 | - |
dc.identifier.pmid | 26568264 | - |
dc.contributor.alternativeName | Kim, Yon Jung | - |
dc.contributor.alternativeName | Moon, Seok Jun | - |
dc.contributor.alternativeName | Lee, Min Goo | - |
dc.contributor.alternativeName | Jeong, Yong Taek | - |
dc.contributor.affiliatedAuthor | Kim, Yon Jung | - |
dc.contributor.affiliatedAuthor | Moon, Seok Jun | - |
dc.contributor.affiliatedAuthor | Lee, Min Goo | - |
dc.contributor.affiliatedAuthor | Jeong, Yong Taek | - |
dc.citation.volume | 6 | - |
dc.citation.startPage | 8867 | - |
dc.identifier.bibliographicCitation | NATURE COMMUNICATIONS, Vol.6 : 8867, 2015 | - |
dc.identifier.rimsid | 39874 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.