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Newly designed delta neutrophil index-to-serum albumin ratio prognosis of early mortality in severe sepsis

DC FieldValueLanguage
dc.contributor.author박유석-
dc.contributor.author박은철-
dc.contributor.author유제성-
dc.contributor.author이혜선-
dc.contributor.author정성필-
dc.contributor.author정현수-
dc.contributor.author홍정화-
dc.contributor.author황윤정-
dc.date.accessioned2018-03-26T16:42:01Z-
dc.date.available2018-03-26T16:42:01Z-
dc.date.issued2015-
dc.identifier.issn0735-6757-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/156728-
dc.description.abstractPURPOSE: We evaluated the ratio of delta neutrophil index (DNI) to albumin (A) in patients receiving early goal-directed therapy (EGDT) to determine the prognostic significance of the DNI/A ratio as a marker of early mortality in critically ill patients with suspected sepsis. METHODS: We retrospectively analyzed records from a prospective EGDT registry in an emergency department (ED) and screened eligible adult patients who were admitted to the ED with severe sepsis and/or septic shock. The new DNI/A ratio was calculated as the DNI value on each hospital day divided by the initial albumin level on ED admission. The clinical outcome was mortality after 28 days. RESULTS: A total of 120 patients receiving EGDT were included in this study. Multivariate Cox proportional-hazard models revealed that higher DNI/A ratios on day 1 (hazard ratio [HR], 1.068; 95% confidence interval [CI], 1.01-1.13; P = .0209) and the peak day (HR, 1.057; 95% CI, 1.001-1.116; P = .0456) were independent risk factors for mortality at 28 days. Our study demonstrated that the increased trend toward 28-day mortality was associated with a DNI/A ratio greater than 8.4 on day 1 (HR, 2.513; 95% CI, 0.950-6.64; P = .0528) and a higher DNI/A ratio (>6.4) on the peak day (average, 4.2 days; HR, 2.953; 95% CI, 1.033-8.441; P < .001) in patients with severe sepsis receiving EGDT. CONCLUSION: The ratio of DNI to serum albumin on ED admission is a promising prognostic marker of 28-day mortality in patients with severe sepsis receiving EGDT.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherW B Saunders-
dc.relation.isPartOfAmerican Journal of Emergency Medicine-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers/blood-
dc.subject.MESHEmergency Service, Hospital-
dc.subject.MESHFemale-
dc.subject.MESHHealth Status Indicators*-
dc.subject.MESHHospital Mortality-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeutrophils/metabolism*-
dc.subject.MESHPrognosis-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHRisk Factors-
dc.subject.MESHSepsis/blood-
dc.subject.MESHSepsis/mortality*-
dc.subject.MESHSepsis/therapy-
dc.subject.MESHSerum Albumin/metabolism*-
dc.titleNewly designed delta neutrophil index-to-serum albumin ratio prognosis of early mortality in severe sepsis-
dc.typeArticle-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Emergency Medicine-
dc.contributor.googleauthorYoon Jung Hwang-
dc.contributor.googleauthorSung Phil Chung-
dc.contributor.googleauthorYoo Seok Park-
dc.contributor.googleauthorHyun Soo Chung-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJong Woo Park-
dc.contributor.googleauthorJong Wook Lee-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorJe Sung You-
dc.contributor.googleauthorIncheol Park-
dc.identifier.doi10.1016/j.ajem.2015.06.012-
dc.contributor.localIdA01592-
dc.contributor.localIdA01618-
dc.contributor.localIdA02507-
dc.contributor.localIdA03312-
dc.contributor.localIdA03625-
dc.contributor.localIdA03764-
dc.contributor.localIdA04433-
dc.contributor.localIdA04816-
dc.relation.journalcodeJ00079-
dc.identifier.eissn1532-8171-
dc.identifier.pmid26238097-
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0735675715004842-
dc.contributor.alternativeNamePark, Yoo Seok-
dc.contributor.alternativeNamePark, Eun Chul-
dc.contributor.alternativeNameYou, Je Sung-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameChung, Sung Pil-
dc.contributor.alternativeNameChung, Hyun Soo-
dc.contributor.alternativeNameHong, Jung Hwa-
dc.contributor.alternativeNameHwang, Yoon Jung-
dc.contributor.affiliatedAuthorPark, Yoo Seok-
dc.contributor.affiliatedAuthorPark, Eun Chul-
dc.contributor.affiliatedAuthorYou, Je Sung-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorChung, Sung Pil-
dc.contributor.affiliatedAuthorChung, Hyun Soo-
dc.contributor.affiliatedAuthorHong, Jung Hwa-
dc.contributor.affiliatedAuthorHwang, Yoon Jung-
dc.citation.volume33-
dc.citation.number11-
dc.citation.startPage1577-
dc.citation.endPage1582-
dc.identifier.bibliographicCitationAmerican Journal of Emergency Medicine, Vol.33(11) : 1577-1582, 2015-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Emergency Medicine (응급의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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