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The Effects of Two Non-Steroidal Anti-Inflammatory Drugs, Bromfenac 0.1% and Ketorolac 0.45%, on Cataract Surgery

 Ji Won Jung  ;  Byung Hoon Chung  ;  Eung Kweon Kim  ;  Kyoung Yul Seo  ;  Tae-im Kim 
 YONSEI MEDICAL JOURNAL, Vol.56(6) : 1671-1677, 2015 
Journal Title
Issue Date
Aged ; Anti-Inflammatory Agents, Non-Steroidal/administration & dosage* ; Anti-Inflammatory Agents, Non-Steroidal/pharmacology ; Benzophenones/administration & dosage* ; Benzophenones/pharmacology ; Bromobenzenes/administration & dosage* ; Bromobenzenes/pharmacology ; Cataract* ; Cataract Extraction* ; Female ; Humans ; Inflammation/prevention & control ; Ketorolac/administration & dosage* ; Ketorolac/pharmacology ; Lens Implantation, Intraocular ; Macular Edema/prevention & control* ; Male ; Middle Aged ; Miosis/prevention & control* ; Phacoemulsification ; Postoperative Complications/drug therapy ; Postoperative Period ; Premedication ; Treatment Outcome
Non-steroidal anti-inflammatory drugs ; miosis ; ocular inflammation ; macular edema
PURPOSE: To compare the additive effects of two types of non-steroidal anti-inflammatory drugs (NSAIDs), bromfenac 0.1% or ketorolac 0.45%, relative to topical steroid alone in cataract surgery.

MATERIALS AND METHODS: A total 91 subjects scheduled to undergo cataract operation were randomized into three groups: Group 1, pre/postoperative bromfenac 0.1%; Group 2, pre/postoperative preservative-free ketorolac 0.45%; and Group 3, postoperative steroid only, as a control. Outcome measures included intraoperative change in pupil size, postoperative anterior chamber inflammation control, change in macular thickness and volume, and ocular surface status after operation.

RESULTS: Both NSAID groups had smaller intraoperative pupil diameter changes compared to the control group (p<0.05). There was significantly less ocular inflammation 1 week and 1 month postoperatively in both NSAID groups than the control group. The changes in central foveal subfield thickness measured before the operation and at postoperative 1 month were 4.30±4.25, 4.87±6.03, and 12.47±12.24 μm in groups 1 to 3, respectively. In the control group, macular thickness and volume increased more in patients with diabetes mellitus (DM), compared to those without DM. In contrast, in both NSAID groups, NSAIDs significantly reduced macular changes in subgroups of patients with or without DM. Although three ocular surface parameters were worse in group 1 than in group 2, these differences were not significant.

CONCLUSION: Adding preoperative and postoperative bromfenac 0.1% or ketorolac 0.45% to topical steroid can reduce intraoperative miosis, postoperative inflammation, and macular changes more effectively than postoperative steroid alone.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Eung Kweon(김응권) ORCID logo https://orcid.org/0000-0002-1453-8042
Kim, Tae-Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
Chung, Byung Hoon(정병훈)
Jung, Ji Won(정지원)
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