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Drug-loaded gold/iron/gold plasmonic nanoparticles for magnetic targeted chemo-photothermal treatment of rheumatoid arthritis

Authors
 Hyung Joon Kim  ;  Sun-Mi Lee  ;  Kyu-Hyung Park  ;  Chin Hee Mun  ;  Yong-Beom Park  ;  Kyung-Hwa Yoo 
Citation
 BIOMATERIALS, Vol.61 : 95-102, 2015 
Journal Title
BIOMATERIALS
ISSN
 0142-9612 
Issue Date
2015
MeSH
Animals ; Antirheumatic Agents/administration & dosage ; Arthritis, Rheumatoid/drug therapy* ; Arthritis, Rheumatoid/pathology* ; Combined Modality Therapy/methods ; Contrast Media/chemical synthesis ; Delayed-Action Preparations/administration & dosage ; Delayed-Action Preparations/chemical synthesis ; Diffusion ; Gold/chemistry ; Gold/therapeutic use ; Iron/chemistry ; Iron/therapeutic use ; Light ; Magnetic Fields ; Male ; Metal Nanoparticles/chemistry* ; Metal Nanoparticles/ultrastructure ; Methotrexate/administration & dosage* ; Methotrexate/chemistry ; Mice ; Mice, Inbred DBA ; Molecular Imaging/methods ; Nanocapsules/chemistry ; Nanocapsules/radiation effects ; Nanocapsules/therapeutic use* ; Particle Size ; Photochemotherapy/methods* ; Photosensitizing Agents/administration & dosage ; Photosensitizing Agents/chemistry ; Surface Plasmon Resonance/methods ; Theranostic Nanomedicine/methods ; Treatment Outcome
Keywords
Drug-loaded Au plasmonic nanoparticles ; Drug-loaded Au/Fe/Au plasmonic nanoparticles ; chemo-photothermal treatment ; photothermally controlled drug delivery, multidrug resistance in cancer, rheumatoid arthritis
Abstract
We have developed methotrexate (MTX)-loaded poly(lactic-co-glycolic acid, PLGA) gold (Au)/iron (Fe)/gold (Au) half-shell nanoparticles conjugated with arginine-glycine-aspartic acid (RGD), which can be applied for magnetic targeted chemo-photothermal treatment, and in vivo multimodal imaging of rheumatoid arthritis (RA). Upon near-infrared (NIR) irradiation, local heat is generated at the inflammation region due to the NIR resonance of Au half-shells and MTX release from PLGA nanoparticles is accelerated. The Fe half-shell layer embedded between the Au half-shell layers enables in vivo T2-magnetic resonance (MR) imaging in addition to NIR absorbance imaging. Furthermore, the delivery of the nanoparticles to the inflammation region in collagen-induced arthritic (CIA) mice, and their retention can be enhanced under external magnetic field. When combined with consecutive NIR irradiation and external magnetic field application, these nanoparticles provide enhanced therapeutic effects with an MTX dosages of only 0.05% dosage compared to free MTX therapy for the treatment of RA.
Full Text
https://www.sciencedirect.com/science/article/pii/S0142961215004688
DOI
10.1016/j.biomaterials.2015.05.018
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Mun, Chin Hee(문진희)
Park, Yong Beom(박용범)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156699
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