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Updates in the Pathogenesis of Rosacea

Authors
 Jung Min Lim  ;  Sang Eun Lee  ;  Seung Hun Lee 
Citation
 Journal of Skin Barrier Research (한국피부장벽학회지), Vol.17(1) : 20-26, 2015 
Journal Title
 Journal of Skin Barrier Research (한국피부장벽학회지) 
ISSN
 1229-4934 
Issue Date
2015
Keywords
Cathelicidin ; ER stress ; Mast cell ; Rosacea ; TLR2 ; TRPA1 ; TRPV1
Abstract
Rosacea is a common, chronic inflammatory disorder of the skin, with central facial erythema and inflammatory papules and pustules as the commonly recognized features. Although the exact pathogenesis of rosacea is unknown, dysregulation of the innate immune system, neurovascular dysregulation and overgrowth of commensal skin organisms are thought to be involved in the pathophysiology of rosacea. Various receptors and mediators, including cathelicidin, endoplasmic reticulum(ER) stress, toll-like receptor(TLR) 2, protease-activated receptor(PAR) 2, transient receptor potential(TRP)s, and mast cells, express important functions in each aspect. They are also intimately connected and form a proinflammatory cascade, which ultimately results in the development of clinical symptoms presented in rosacea. In this review, we briefly summarize key factors and recent studies about the updated pathogenesis of rosacea.
Full Text
http://www.papersearch.net/thesis/article.asp?KEY=3429812
DOI
2015
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Dermatology (피부과학교실) > 1. Journal Papers
Yonsei Authors
Lee, Sang Eun(이상은) ORCID logo https://orcid.org/0000-0003-4720-9955
Lee, Seung Hun(이승헌)
Lim, Jung Min(임정민) ORCID logo https://orcid.org/0000-0002-0223-5933
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/156695
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