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Comparison of Surrogate Markers as Measures of Uncomplicated Insulin Resistance in Korean Adults

DC FieldValueLanguage
dc.contributor.author김혜정-
dc.contributor.author이지원-
dc.contributor.author이혜선-
dc.contributor.author홍정화-
dc.date.accessioned2018-01-23T05:53:30Z-
dc.date.available2018-01-23T05:53:30Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/155784-
dc.description.abstractBACKGROUND: Metabolic syndrome (MS) is known to increase the risk of various cardiometabolic diseases and in-sulin resistance (IR) has known to have central role in the development of MS. Many surrogate indices of IR have been proposed and the detection of MS might be a suitable model for assessing the accuracy of surrogate indices. The aims of our study are to invest the most appropriate index by assessment of the diagnostic capacity of IR among each surrogate index and identifying cut-off values for discriminating uncomplicated MS in Korean adults. METHODS: A cross-sectional study was performed, assessing 294 Korean adults, 85 of whom were diagnosed with uncomplicated MS. The sensitivities and specificities of five surrogate IR indices were compared to discriminate MS from healthy subjects; these included fasting serum insulin, homeostasis model assessment-insulin resistance index, quantitative insulin sensitivity check index, McAuley index, and Disse index. Correlations between each index value were assessed using Pearson's and Spearman's correlation methods. RESULTS: The McAuley index showed the highest area under the curve (0.85), specificity (86.12%), accuracy (82.31%), positive predictive value (68.13%), and negative predictive value (88.67%) to distinguish MS, with a cut-off point of 5.3 defined. Correlation coefficients of the five indices showed that the McAuley index had the strongest correlation with IR. CONCLUSION: The McAuley index showed the best accuracy in the detection of MS as a surrogate marker of IR. To establish more effective and accurate standards of measuring IR, comprehensive and multi-scaled studies are required.-
dc.description.statementOfResponsibilityopen-
dc.relation.isPartOfKorean Journal of Family Medicine (가정의학회지)-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rightshttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleComparison of Surrogate Markers as Measures of Uncomplicated Insulin Resistance in Korean Adults-
dc.typeArticle-
dc.contributor.collegeDept. of Family Medicine-
dc.contributor.departmentCollege of Medicine-
dc.contributor.googleauthorTae Jong Kim-
dc.contributor.googleauthorHye Jung Kim-
dc.contributor.googleauthorYoung Bae Kim-
dc.contributor.googleauthorJee Yon Lee-
dc.contributor.googleauthorHye Sun Lee-
dc.contributor.googleauthorJung Hwa Hong-
dc.contributor.googleauthorJi Won Lee-
dc.identifier.doi10.4082/kjfm.2016.37.3.188-
dc.contributor.localIdA05198-
dc.contributor.localIdA03203-
dc.contributor.localIdA03312-
dc.contributor.localIdA04433-
dc.relation.journalcodeJ02007-
dc.identifier.pmid27274391-
dc.contributor.alternativeNameKim, Hye Jung-
dc.contributor.alternativeNameLee, Ji Won-
dc.contributor.alternativeNameLee, Hye Sun-
dc.contributor.alternativeNameHong, Jung Hwa-
dc.contributor.affiliatedAuthorKim, Hye Jung-
dc.contributor.affiliatedAuthorLee, Ji Won-
dc.contributor.affiliatedAuthorLee, Hye Sun-
dc.contributor.affiliatedAuthorHong, Jung Hwa-
dc.citation.volume37-
dc.citation.number3-
dc.citation.startPage188-
dc.citation.endPage196-
dc.identifier.bibliographicCitationKorean Journal of Family Medicine (가정의학회지), Vol.37(3) : 188-196, 2016-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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