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Occurrence and prenatal exposure to persistent organic pollutants using meconium in Korea: Feasibility of meconium as a non-invasive human matrix

 Yunsun Jeong  ;  Sunggyu Lee  ;  Sunmi Kim  ;  Sung-Deuk Choi  ;  Jeongim Park  ;  Hai-Joong Kim  ;  Jeong Jae Lee  ;  Gyuyeon Choi  ;  Sooran Choi  ;  Sungjoo Kim  ;  Su Young Kim  ;  Young Don Kim  ;  Geumjoon Cho  ;  Eunsook Suh  ;  SungKoo Kim  ;  So-Hee Eun  ;  Soyong Eom  ;  Seunghyo Kim  ;  Gun-Ha Kim  ;  Sungkyoon Kim  ;  Kyungho Choi  ;  Hyo-Bang Moon 
 ENVIRONMENTAL RESEARCH, Vol.147 : 8-15, 2016 
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Prenatal exposure to persistent organic pollutants (POPs) is of great concern due to the vulnerability of fetus. Nineteen Polychlorinated biphenyls (PCBs), 18 organochlorine pesticides (OCPs) including DDTs, HCHs, chlordanes, and hexachlorobenzene, and 22 polybrominated diphenyl ethers (PBDEs) were measured in meconium samples from 72 newborn infants using high resolution gas chromatography/mass spectrometry. The median concentrations (on wet weight basis) of PCBs, OCPs, and PBDEs were 26.8pg/g, 66.7pg/g, and 2.32pg/g, respectively. Highly significant correlations were observed among the compounds of PCBs and OCPs, suggesting their similar sources and kinetic behaviors. BDE 47 had significant correlations with PCBs and OCPs, whereas BDE 209 was not correlated with any of the contaminants due to different exposure sources. The concentrations of p,p'-DDE, β-HCH, and trans-nonaCHL between paired maternal blood-meconium and cord blood-meconium showed significant correlations, while PCBs and PBDEs were not significantly correlated in the paired samples. Maternal age and gestational age were demographic parameters affecting POP levels in meconium. Multiple regression analysis showed that the levels of several OCPs in cord and maternal serum were contributing factors governing the levels of these contaminants in meconium. Our results indicate that meconium can be utilized as a human matrix for prenatal exposure to several OCPs.
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5. Research Institutes (연구소) > Epilepsy Research Institute (뇌전증연구소) > 1. Journal Papers
Yonsei Authors
Eom, So Yong(엄소용)
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