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Effect of two lipid-lowering strategies on high-density lipoprotein function and some HDL-related proteins: a randomized clinical trial

Authors
 Chan Joo Lee  ;  Seungbum Choi  ;  Dong Huey Cheon  ;  Kyeong Yeon Kim  ;  Eun Jeong Cheon  ;  Soo-jin Ann  ;  Hye-Min Noh  ;  Sungha Park  ;  Seok-Min Kang  ;  Donghoon Choi  ;  Ji Eun Lee  ;  Sang-Hak Lee 
Citation
 LIPIDS IN HEALTH AND DISEASE, Vol.16(1) : 49, 2017 
Journal Title
 LIPIDS IN HEALTH AND DISEASE 
Issue Date
2017
MeSH
Anticholesteremic Agents/pharmacology ; Anticholesteremic Agents/therapeutic use* ; Apolipoproteins/blood* ; Atorvastatin Calcium/pharmacology ; Atorvastatin Calcium/therapeutic use* ; Cholesterol, HDL/blood* ; Drug Therapy, Combination ; Ezetimibe/pharmacology ; Ezetimibe/therapeutic use* ; Female ; Humans ; Hypercholesterolemia/blood ; Hypercholesterolemia/drug therapy* ; Male ; Middle Aged ; Treatment Outcome ; Vascular Cell Adhesion Molecule-1/blood
Keywords
Atorvastatin calcium ; Cholesterol-efflux regulatory protein ; Ezetimibe ; Inflammation
Abstract
BACKGROUND: The influence of lipid-lowering therapy on high-density lipoprotein (HDL) is incompletely understood. We compared the effect of two lipid-lowering strategies on HDL functions and identified some HDL-related proteins. METHODS: Thirty two patients were initially screened and HDLs of 21 patients were finally analyzed. Patients were randomized to receive atorvastatin 20 mg (n = 11) or atorvastatin 5 mg/ezetimibe 10 mg combination (n = 10) for 8 weeks. The cholesterol efflux capacity and other anti-inflammatory functions were assessed based on HDLs of the participants before and after treatment. Pre-specified HDL proteins of the same HDL samples were measured. RESULTS: The post-treatment increase in cholesterol efflux capacities was similar between the groups (35.6% and 34.6% for mono-therapy and combination, respectively, p = 0.60). Changes in nitric oxide (NO) production, vascular cell adhesion molecule-1 (VCAM-1) expression, and reactive oxygen species (ROS) production were similar between the groups. The baseline cholesterol efflux capacity correlated positively with apolipoprotein (apo)A1 and C3, whereas apoA1 and apoC1 showed inverse associations with VCAM-1 expression. The changes in the cholesterol efflux capacity were positively correlated with multiple HDL proteins, especially apoA2. CONCLUSIONS: Two regimens increased the cholesterol efflux capacity of HDL comparably. Multiple HDL proteins, not limited to apoA1, showed a correlation with HDL functions. These results indicate that conventional lipid therapy may have additional effects on HDL functions with changes in HDL proteins. TRIAL REGISTRATION: ClinicalTrials.gov, number NCT02942602 .
Files in This Item:
T201700461.pdf Download
DOI
10.1186/s12944-017-0433-6.
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Seok Min(강석민) ORCID logo https://orcid.org/0000-0001-9856-9227
Park, Sung Ha(박성하) ORCID logo https://orcid.org/0000-0001-5362-478X
Lee, Sang Hak(이상학) ORCID logo https://orcid.org/0000-0002-4535-3745
Choi, Dong Hoon(최동훈) ORCID logo https://orcid.org/0000-0002-2009-9760
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154680
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