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Assessment of the Tear Meniscus by Strip Meniscometry and Keratograph in Patients With Dry Eye Disease According to the Presence of Meibomian Gland Dysfunction

 Kang Won Lee  ;  Jung Yong Kim  ;  Hee Seung Chin  ;  Kyoung Yul Seo  ;  Tae-im Kim  ;  Ji Won Jung 
 CORNEA, Vol.36(2) : 189-195, 2017 
Journal Title
Issue Date
Adult ; Aged ; Area Under Curve ; Diagnostic Techniques, Ophthalmological/instrumentation* ; Dry Eye Syndromes/diagnosis* ; Dry Eye Syndromes/metabolism ; Eyelid Diseases/diagnosis* ; Eyelid Diseases/metabolism ; Female ; Humans ; Male ; Meibomian Glands/metabolism ; Meibomian Glands/pathology* ; Middle Aged ; ROC Curve ; Tears/chemistry* ; Young Adult
keratograph ; strip meniscometry ; tear meniscus, dry eye disease
PURPOSE: We aimed to compare the tear meniscus measurements using strip meniscometry (SM) and Keratograph5M (K5M) between 3 subtypes of dry eye disease patient groups, classified according to the presence of meibomian gland dysfunction (MGD), and normal subjects. METHODS: We enrolled 145 eyes from 145 subjects and measured the tear meniscus using SM and K5M, tear film breakup time, ocular surface staining, and ocular surface disease index; the Schirmer test; and examined lid margins and meibomian glands. Correlation of tear meniscus parameters with other parameters and efficacy of the 2 measurements were evaluated. RESULTS: The SM and K5M results were significantly lower in the non-Sjögren syndrome aqueous-deficient dry eye (non-SS ADDE) with and without MGD groups than in the MGD-only group and normal subjects. The SM or K5M results correlated with each other and with other ocular surface parameters. The area under the curve (AUC) of the SM and K5M results was 0.637 (P = 0.012) and 0.610 (P = 0.042), respectively. Except for the MGD group, the AUC of the SM and K5M results were 0.721 (P < 0.001) and 0.694 (P = 0.001), respectively. The AUC of SM and K5M were 0.947 (P < 0.001) and 0.784 (P = 0.002), differentiating non-SS ADDE-only patients from those with normal eyes. CONCLUSIONS: Tear meniscus measurements using SM and K5M can compensate for detection of aqueous-deficient components of dry eye. These results should be interpreted according to the presence or absence of MGD.
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1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Tae Im(김태임) ORCID logo https://orcid.org/0000-0001-6414-3842
Seo, Kyoung Yul(서경률) ORCID logo https://orcid.org/0000-0002-9855-1980
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