0 116

Cited 1 times in

Neutropenia is independently associated with sub-therapeutic serum concentration of vancomycin

Authors
 Min Hyuk Choi  ;  Yeon Hwa Choe  ;  Sang-Guk Lee  ;  Seok Hoon Jeong  ;  Jeong-Ho Kim 
Citation
 Clinica Chimica Acta, Vol.465 : 106-111, 2017 
Journal Title
 Clinica Chimica Acta 
ISSN
 0009-8981 
Issue Date
2017
MeSH
Adult ; Aged ; Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/blood ; Drug Monitoring/methods ; Female ; Humans ; Linear Models ; Male ; Middle Aged ; Neutropenia/chemically induced* ; Retrospective Studies ; Vancomycin/adverse effects* ; Vancomycin/blood*
Abstract
BACKGROUND: We aimed to identify the impact of the presence of neutropenia on serum vancomycin concentration (SVC). METHODS: A retrospective study was conducted from January 2005 to December 2015. The study population was comprised of adult patients who were performed serum concentration of vancomycin. Patients with renal failure or using non-conventional dosages of vancomycin were excluded. RESULTS: A total of 1307 adult patients were included in this study, of whom 163 (12.4%) were neutropenic. Patients with neutropenia presented significantly lower SVCs than non-neutropenic patients (P<0.0001). Multiple linear regressions showed significant association between neutropenia and trough SVC (beta coefficients, -2.351; P=0.004). Multiple logistic regression analysis also revealed a significant association between sub-therapeutic vancomycin concentrations (trough SVC values<10mg/l) and neutropenia (odds ratio, 1.75, P=0.029) CONCLUSIONS: The presence of neutropenia is significantly associated with low SVC, even after adjusting for other variables. Therefore, neutropenic patients had a higher risk of sub-therapeutic SVC compared with non-neutropenic patients. We recommended that vancomycin therapy should be monitored with TDM-guided optimization of dosage and intervals, especially in neutropenic patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0009898116305253
DOI
10.1016/j.cca.2016.12.021
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
김정호(Kim, Jeong Ho) ORCID logo https://orcid.org/0000-0003-2479-0548
이상국(Lee, Sang-Guk) ORCID logo https://orcid.org/0000-0003-3862-3660
정석훈(Jeong, Seok Hoon) ORCID logo https://orcid.org/0000-0001-9290-897X
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154595
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse