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Neutropenia is independently associated with sub-therapeutic serum concentration of vancomycin

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dc.contributor.author김정호-
dc.contributor.author이상국-
dc.contributor.author정석훈-
dc.date.accessioned2017-11-02T08:32:58Z-
dc.date.available2017-11-02T08:32:58Z-
dc.date.issued2017-
dc.identifier.issn0009-8981-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154595-
dc.description.abstractBACKGROUND: We aimed to identify the impact of the presence of neutropenia on serum vancomycin concentration (SVC). METHODS: A retrospective study was conducted from January 2005 to December 2015. The study population was comprised of adult patients who were performed serum concentration of vancomycin. Patients with renal failure or using non-conventional dosages of vancomycin were excluded. RESULTS: A total of 1307 adult patients were included in this study, of whom 163 (12.4%) were neutropenic. Patients with neutropenia presented significantly lower SVCs than non-neutropenic patients (P<0.0001). Multiple linear regressions showed significant association between neutropenia and trough SVC (beta coefficients, -2.351; P=0.004). Multiple logistic regression analysis also revealed a significant association between sub-therapeutic vancomycin concentrations (trough SVC values<10mg/l) and neutropenia (odds ratio, 1.75, P=0.029) CONCLUSIONS: The presence of neutropenia is significantly associated with low SVC, even after adjusting for other variables. Therefore, neutropenic patients had a higher risk of sub-therapeutic SVC compared with non-neutropenic patients. We recommended that vancomycin therapy should be monitored with TDM-guided optimization of dosage and intervals, especially in neutropenic patients.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfCLINICA CHIMICA ACTA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAnti-Bacterial Agents/adverse effects-
dc.subject.MESHAnti-Bacterial Agents/blood-
dc.subject.MESHDrug Monitoring/methods-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeutropenia/chemically induced*-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHVancomycin/adverse effects*-
dc.subject.MESHVancomycin/blood*-
dc.titleNeutropenia is independently associated with sub-therapeutic serum concentration of vancomycin-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorMin Hyuk Choi-
dc.contributor.googleauthorYeon Hwa Choe-
dc.contributor.googleauthorSang-Guk Lee-
dc.contributor.googleauthorSeok Hoon Jeong-
dc.contributor.googleauthorJeong-Ho Kim-
dc.identifier.doi10.1016/j.cca.2016.12.021-
dc.contributor.localIdA02810-
dc.contributor.localIdA03619-
dc.contributor.localIdA00903-
dc.relation.journalcodeJ00543-
dc.identifier.eissn1873-3492-
dc.identifier.pmid28025029-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0009898116305253-
dc.contributor.alternativeNameKim, Jeong Ho-
dc.contributor.alternativeNameLee, Sang Guk-
dc.contributor.alternativeNameJeong, Seok Hoon-
dc.contributor.affiliatedAuthorLee, Sang Guk-
dc.contributor.affiliatedAuthorJeong, Seok Hoon-
dc.contributor.affiliatedAuthorKim, Jeong Ho-
dc.citation.titleClinica Chimica Acta-
dc.citation.volume465-
dc.citation.startPage106-
dc.citation.endPage111-
dc.identifier.bibliographicCitationCLINICA CHIMICA ACTA, Vol.465 : 106-111, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43651-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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