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Asymptomatic hyperuricemia is independently associated with coronary artery calcification in the absence of overt coronary artery disease: A single-center cross-sectional study

 Hyunwook Kim  ;  Seok-hyung Kim  ;  Ah Ran Choi  ;  Seungkyu Kim  ;  Hoon Young Choi  ;  Hyung Jong Kim  ;  Hyeong-Cheon Park 
 MEDICINE, Vol.96(14) : 6-565, 2017 
Journal Title
Issue Date
Adult ; Aged ; Asymptomatic Diseases ; Coronary Artery Disease/blood* ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnostic imaging ; Cross-Sectional Studies ; Female ; Humans ; Hyperuricemia/complications ; Male ; Middle Aged ; Multidetector Computed Tomography ; Retrospective Studies ; Uric Acid/blood* ; Vascular Calcification/blood* ; Vascular Calcification/complications ; Vascular Calcification/diagnostic imaging
coronary artery calcification ; coronary artery calcium scores ; health examination ; uric acid
Recently, the pathogenic role of uric acid (UA) in both systemic metabolic and atherosclerotic diseases has been investigated. We sought to determine the independent correlation between serum UA levels and coronary artery calcification, as a marker of subclinical atherosclerosis. A total of 4188 individuals without prior coronary artery disease or urate-deposition disease were included. All of the participants underwent multidetector computed tomography (MDCT) for the evaluation of coronary artery calcification (CAC) during their health check-ups. The subjects were divided into thre groups according to CAC scores (group 1: 0; group 2: 1-299; group 3: ≥300). After controlling for other confounders, serum UA levels were found to be positively associated with increasing CAC scores (P = 0.001). Adjusted mean serum UA levels in each CAC group were estimated to be 5.2 ± 0.1 mg/dL, 5.3 ± 0.1 mg/dL, and 5.6 ± 0.2 mg/dL from groups 1, 2, and 3, respectively. Subsequent subgroup analyses revealed that this positive association was only significant in participants who were male, relatively older, less overweight, and did not have diabetes mellitus (DM), hypertension, smoking history, or renal dysfunction. In conclusion, serum uric acid levels were independently associated with CAC score severity and this finding is particularly relevant to the subjects who were male, relatively older, less overweight (body mass index < 25 kg/m), and without a history of DM, hypertension, smoking, or renal dysfunction.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Seok Hyung(김석형)
Kim, Seung Kyu(김승규)
Kim, Hyun Wook(김현욱) ORCID logo https://orcid.org/0000-0002-4274-7562
Park, Hyeong Cheon(박형천) ORCID logo https://orcid.org/0000-0002-1550-0812
Choi, Ah Ran(최아란)
Choi, Hoon Young(최훈영) ORCID logo https://orcid.org/0000-0002-4245-0339
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