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Joint Effect of Cigarette Smoking and Body Mass Index on White Blood Cell Count in Korean Adults

Authors
 A-Ra Cho  ;  Won-Jun Choi  ;  Shin-Hye Kim  ;  Jae-Yong Shim  ;  Yong-Jae Lee 
Citation
 Korean Journal of Family Medicine, Vol.38(2) : 75-80, 2017 
Journal Title
 Korean Journal of Family Medicine (가정의학회지) 
ISSN
 2005-6443 
Issue Date
2017
Keywords
Leukocyte Count ; Obesity ; Smoking
Abstract
BACKGROUND: White blood cell count is an independent risk factor for cardiovascular disease. Several lifestyle and metabolic factors such as cigarette smoking and obesity are known to be associated with an elevated white blood cell count. However, the joint effect of cigarette smoking and obesity on white blood cell count has not yet been fully described. METHODS: We explored the joint effect of cigarette smoking and obesity on white blood cell count using multiple logistic regression analyses after adjusting for confounding variables in a population-based, cross-sectional study of 416,065 Korean adults. RESULTS: Cigarette smoking and body mass index have a dose-response relationship with a higher white blood cell count, but no synergistic interaction is observed between them (men, P for interaction=0.797; women, P for interaction=0.311). Cigarette smoking and body mass index might have an additive combination effect on high white blood cell count. Obese male smokers were 2.36 times more likely and obese female smokers 2.35 times more likely to have a high white blood cell count when compared with normal body mass index non-smokers. CONCLUSION: Cigarette smoking and body mass index are independently associated with an elevated white blood cell count in both men and women.
Files in This Item:
T201700874.pdf Download
DOI
10.4082/kjfm.2017.38.2.75
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Family Medicine (가정의학교실) > 1. Journal Papers
Yonsei Authors
Shim, Jae Yong(심재용) ORCID logo https://orcid.org/0000-0002-9561-9230
Lee, Yong Jae(이용제) ORCID logo https://orcid.org/0000-0002-6697-476X
Cho, A Ra(조아라) ORCID logo https://orcid.org/0000-0002-3645-2282
Choi, Won Jun(최원준) ORCID logo https://orcid.org/0000-0002-8233-9272
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154543
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