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The incidence and clinical characteristics by gender differences in patients with Kikuchi-Fujimoto disease

 In Young Jung  ;  Hea Won Ann  ;  Jung Ju Kim  ;  Se Ju Lee  ;  Jinnam Kim  ;  Hye Seong  ;  Dong Hyun Oh  ;  Yong Chan Kim  ;  Eun Jin Kim  ;  Su Jin Jeong  ;  Nam Su Ku  ;  Jun Yong Choi  ;  Young Goo Song  ;  June Myung Kim 
 Medicine, Vol.96(11) : 6332-6332, 2017 
Journal Title
Issue Date
Adult ; Antibodies, Antinuclear/blood ; C-Reactive Protein/analysis ; Cross-Sectional Studies ; Female ; Histiocytic Necrotizing Lymphadenitis/epidemiology* ; Histiocytic Necrotizing Lymphadenitis/physiopathology* ; Humans ; Incidence ; L-Lactate Dehydrogenase/blood ; Liver Function Tests ; Male ; Middle Aged ; Republic of Korea/epidemiology ; Retrospective Studies ; Sex Factors
characteristics ; Kikuchi–Fujimoto disease ; males
Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting disorder that typically affects the cervical lymph nodes (LNs). Although initially described in young women, KFD also occurs in men. There are no reports on the clinical manifestations and characteristics of male KFD patients. Therefore, this study was conducted to assess the incidence of KFD among males, as well as the most frequent clinical characteristics of these patients. A retrospective, cross-sectional study was performed at a tertiary hospital of patients pathologically confirmed as having KFD from LN biopsy specimens. Clinical and laboratory data, and treatment outcomes of the enrolled patients, were analyzed by gender. A total of 254 patients diagnosed with KFD were enrolled. There were 189 females and 65 males (2.9:1). The mean age was 32.6 ± 11.3 years. Compared to the female patients, the males had more frequent manifestations of fever (48% vs 67%, P = 0.008), headache (9% vs 20%, P = 0.013), bilateral lymphadenopathy (31% vs 46%, P = 0.029), thrombocytopenia (14% vs 29%, P = 0.014), elevated C-reactive protein (CRP) (35% vs 78.4%, P < 0.001), elevated liver enzymes (15% vs 41%, P < 0.001), and elevated lactate dehydrogenase (LDH) (61% vs 80%, P = 0.021). Male patients had fewer autoimmune features (9% vs 2%, P = 0.043) and fewer positive antinuclear antibodies (32% vs 10%, P = 0.006). In this study, 25.6% of the enrolled patients were male, with a 2.9:1 female-to-male sex ratio. Male patients showed a distinctive profile characterized by a higher frequency of fever, headache, bilateral lymphadenopathy, and thrombocytopenia, as well as elevated liver enzymes, CRP, and LDH.
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1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김용찬(Kim, Yong Chan)
김은진(Kim, Eun Jin)
김정주(Kim, Jung Ju)
김준명(Kim, June Myung)
김진남(Kim, Jin Nam)
성혜(Seong, Hye) ORCID logo https://orcid.org/0000-0002-5633-7214
송영구(Song, Young Goo) ORCID logo https://orcid.org/0000-0002-0733-4156
오동현(Oh, Dong Hyun)
이세주(Lee, Se Ju)
정수진(Jeong, Su Jin)
정인영(Jung, In Young)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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