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Effects of Alendronate on Bone Remodeling Around Osseointegrated Implants in Rats

 Kyung Chul Oh  ;  Woojin Hwang  ;  Young Bum Park  ;  Jae Hoon Lee  ;  Hong Seok Moon  ;  Jee Hwan Kim 
 IMPLANT DENTISTRY, Vol.26(1) : 46-53, 2017 
Journal Title
Issue Date
Alendronate/pharmacology* ; Animals ; Bone Density Conservation Agents/pharmacology* ; Bone Remodeling/drug effects* ; Dental Implantation, Endosseous/methods* ; Male ; Osseointegration/drug effects ; Rats ; Rats, Sprague-Dawley ; X-Ray Microtomography
bisphosphonate ; periimplant bone ; medication-related osteonecrosis of the jaw (MRONJ) ; bisphosphonate-related osteonecrosis of the jaw ; serum carboxy terminal telopeptide of type I collagen (s-CTX) ; serum osteocalcin (s-OC)
OBJECTIVE: To determine the effects of alendronate on bone remodeling around osseointegrated implants in rats. MATERIALS AND METHODS: The maxillary first molars were extracted from 36 male Sprague-Dawley rats, and replaced with customized implants. They were then administered twice-weekly subcutaneous injections of either alendronate (alendronate group) or saline (control group) after allowing a 4-week period for osseointegration. They were killed at 4, 8, or 12 weeks after the commencement of the injection protocol, and the implant sites were evaluated comprehensively by microcomputed tomographic, histologic, and biochemical assessments. RESULTS: It was hard to find statistically significant differences from microcomputed tomographic analyses. In addition, inconsistent variations were derived from histologic data. However, biochemical data showed statistically significant differences; serum osteocalcin level was statistically significantly lower in the alendronate group than in the control group at 8 weeks after the commencement of injections. In addition, serum osteocalcin level in the alendronate group was statistically significantly lower at 8 and 12 weeks after the initial injection point than at preinjection. CONCLUSIONS: The results suggest alendronate might affect bone remodeling activity around osseointegrated implants negatively, and serum osteocalcin could serve as an accessory tool to evaluate this effect.
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2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jee Hwan(김지환) ORCID logo https://orcid.org/0000-0002-0872-4906
Moon, Hong Seok(문홍석) ORCID logo https://orcid.org/0000-0001-8118-8145
Park, Young Bum(박영범)
Oh, Kyung Chul(오경철) ORCID logo https://orcid.org/0000-0003-4584-2597
Lee, Jae Hoon(이재훈) ORCID logo https://orcid.org/0000-0003-2281-8885
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