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Effects of Alendronate on Bone Remodeling Around Osseointegrated Implants in Rats

DC Field Value Language
dc.contributor.author김지환-
dc.contributor.author문홍석-
dc.contributor.author박영범-
dc.contributor.author오경철-
dc.contributor.author이재훈-
dc.date.accessioned2017-11-02T08:28:48Z-
dc.date.available2017-11-02T08:28:48Z-
dc.date.issued2017-
dc.identifier.issn1056-6163-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154513-
dc.description.abstractOBJECTIVE: To determine the effects of alendronate on bone remodeling around osseointegrated implants in rats. MATERIALS AND METHODS: The maxillary first molars were extracted from 36 male Sprague-Dawley rats, and replaced with customized implants. They were then administered twice-weekly subcutaneous injections of either alendronate (alendronate group) or saline (control group) after allowing a 4-week period for osseointegration. They were killed at 4, 8, or 12 weeks after the commencement of the injection protocol, and the implant sites were evaluated comprehensively by microcomputed tomographic, histologic, and biochemical assessments. RESULTS: It was hard to find statistically significant differences from microcomputed tomographic analyses. In addition, inconsistent variations were derived from histologic data. However, biochemical data showed statistically significant differences; serum osteocalcin level was statistically significantly lower in the alendronate group than in the control group at 8 weeks after the commencement of injections. In addition, serum osteocalcin level in the alendronate group was statistically significantly lower at 8 and 12 weeks after the initial injection point than at preinjection. CONCLUSIONS: The results suggest alendronate might affect bone remodeling activity around osseointegrated implants negatively, and serum osteocalcin could serve as an accessory tool to evaluate this effect.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWilliams & Wilkins-
dc.relation.isPartOfIMPLANT DENTISTRY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAlendronate/pharmacology*-
dc.subject.MESHAnimals-
dc.subject.MESHBone Density Conservation Agents/pharmacology*-
dc.subject.MESHBone Remodeling/drug effects*-
dc.subject.MESHDental Implantation, Endosseous/methods*-
dc.subject.MESHMale-
dc.subject.MESHOsseointegration/drug effects-
dc.subject.MESHRats-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHX-Ray Microtomography-
dc.titleEffects of Alendronate on Bone Remodeling Around Osseointegrated Implants in Rats-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Prosthodontics-
dc.contributor.googleauthorKyung Chul Oh-
dc.contributor.googleauthorWoojin Hwang-
dc.contributor.googleauthorYoung Bum Park-
dc.contributor.googleauthorJae Hoon Lee-
dc.contributor.googleauthorHong Seok Moon-
dc.contributor.googleauthorJee Hwan Kim-
dc.identifier.doi10.1097/ID.0000000000000497-
dc.contributor.localIdA01395-
dc.contributor.localIdA01567-
dc.contributor.localIdA04976-
dc.contributor.localIdA03091-
dc.contributor.localIdA01006-
dc.relation.journalcodeJ01041-
dc.identifier.eissn1538-2982-
dc.identifier.pmid27779611-
dc.identifier.urlhttp://ovidsp.ovid.com/ovidweb.cgi?T=JS&CSC=Y&NEWS=N&PAGE=fulltext&AN=00008505-201702000-00008&LSLINK=80&D=ovft-
dc.subject.keywordbisphosphonate-
dc.subject.keywordperiimplant bone-
dc.subject.keywordmedication-related osteonecrosis of the jaw (MRONJ)-
dc.subject.keywordbisphosphonate-related osteonecrosis of the jaw-
dc.subject.keywordserum carboxy terminal telopeptide of type I collagen (s-CTX)-
dc.subject.keywordserum osteocalcin (s-OC)-
dc.contributor.alternativeNameKim, Jee Hwan-
dc.contributor.alternativeNameMoon, Hong Seok-
dc.contributor.alternativeNamePark, Young Bum-
dc.contributor.alternativeNameOh, Kyung Chul-
dc.contributor.alternativeNameLee, Jae Hoon-
dc.contributor.affiliatedAuthorMoon, Hong Seok-
dc.contributor.affiliatedAuthorPark, Young Bum-
dc.contributor.affiliatedAuthorOh, Kyung Chul-
dc.contributor.affiliatedAuthorLee, Jae Hoon-
dc.contributor.affiliatedAuthorKim, Jee Hwan-
dc.citation.titleImplant Dentistry-
dc.citation.volume26-
dc.citation.number1-
dc.citation.startPage46-
dc.citation.endPage53-
dc.identifier.bibliographicCitationIMPLANT DENTISTRY, Vol.26(1) : 46-53, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid43561-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Prosthodontics (보철과학교실) > 1. Journal Papers

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