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Risk factors for visual field progression of normal-tension glaucoma in patients with myopia

Authors
 Hyoung Won Bae  ;  Sang Jin Seo  ;  Sang Yeop Lee  ;  Yun Ha Lee  ;  Samin Hong  ;  Gong Je Seong  ;  Chan Yun Kim 
Citation
 CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE, Vol.52(1) : 107-113, 2017 
Journal Title
 CANADIAN JOURNAL OF OPHTHALMOLOGY-JOURNAL CANADIEN D OPHTALMOLOGIE 
ISSN
 0008-4182 
Issue Date
2017
MeSH
Adult ; Aged ; Disease Progression ; Female ; Follow-Up Studies ; Humans ; Low Tension Glaucoma/complications ; Low Tension Glaucoma/diagnosis* ; Low Tension Glaucoma/physiopathology ; Male ; Middle Aged ; Myopia/complications ; Myopia/diagnosis* ; Myopia/physiopathology ; Retinal Ganglion Cells/pathology* ; Retrospective Studies ; Risk Factors ; Scotoma/diagnosis ; Scotoma/etiology* ; Scotoma/physiopathology ; Time Factors ; Tomography, Optical Coherence/methods ; Visual Fields/physiology* ; Young Adult
Abstract
OBJECTIVE: To identify risk factors for visual field progression of normal-tension glaucoma (NTG) in patients with myopia. DESIGN: Longitudinal, observational study. PARTICIPANTS: Fifty-one eyes of 51 NTG patients with myopia (less than -0.75D based on spherical equivalence) who had undergone visual field (VF) testing at least once per year for ≥6 years between November 2005 and December 2013. METHODS: Progression was defined using event-based guided progression analysis. Risk factors were analyzed using the Cox proportional hazards model and further tested for independence in a multivariate model. RESULTS: The mean observation period was 7.0 ± 1.3 years, and 16 of 51 subjects showed progression. In the univariate analysis, abnormal retinal nerve fibre layer (RNFL) colour codes (yellow or red sector) at the 11, 10, and 7 o'clock positions on optical coherence tomography showed significant associations with the VF progression (p = 0.03, 0.03, and 0.01, respectively). In the final multivariate models, the abnormal RNFL colour code of the 7 o'clock sector (inferotemporal sector) was the only significant risk factor for progression (hazard ratio = 4.07 and 4.37; 95% CI, 1.11-14.92 and 1.27-15.04; p = 0.03 and 0.02, respectively). CONCLUSIONS: Inferotemporal RNFL thinning could be a risk factor for progression in NTG patients with myopia.
Full Text
http://www.sciencedirect.com/science/article/pii/S0008418215300132
DOI
10.1016/j.jcjo.2016.08.011
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Chan Yun(김찬윤) ORCID logo https://orcid.org/0000-0002-8373-9999
Bae, Hyoung Won(배형원) ORCID logo https://orcid.org/0000-0002-8421-5636
Seong, Gong Je(성공제) ORCID logo https://orcid.org/0000-0002-5456-4296
Lee, Sang Yeop(이상엽) ORCID logo https://orcid.org/0000-0002-3834-7953
Hong, Sa Min(홍사민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154506
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