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Sarcopenia correlates with systemic inflammation in COPD

Authors
 Min Kwang Byun  ;  Eun Na Cho  ;  Joon Chang  ;  Chul Min Ahn  ;  Hyung Jung Kim 
Citation
 International Journal of Chronic Obstructive Pulmonary Disease, Vol.12 : 669-675, 2017 
Journal Title
 International Journal of Chronic Obstructive Pulmonary Disease 
ISSN
 1176-9106 
Issue Date
2017
MeSH
Adult ; Age Factors ; Aged ; Aged, 80 and over ; Biomarkers/blood ; Chi-Square Distribution ; Comorbidity ; Cross-Sectional Studies ; Electric Impedance ; Exercise Tolerance ; Female ; Hand Strength ; Health Status ; Humans ; Inflammation/blood ; Inflammation/diagnosis ; Inflammation/epidemiology* ; Inflammation/physiopathology ; Inflammation Mediators/blood ; Interleukin-6/blood ; Logistic Models ; Lung/physiopathology ; Male ; Middle Aged ; Multivariate Analysis ; Muscle, Skeletal/physiopathology ; Prevalence ; Pulmonary Disease, Chronic Obstructive/blood ; Pulmonary Disease, Chronic Obstructive/diagnosis ; Pulmonary Disease, Chronic Obstructive/epidemiology* ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Republic of Korea/epidemiology ; Risk Factors ; Sarcopenia/blood ; Sarcopenia/diagnosis ; Sarcopenia/epidemiology* ; Sarcopenia/physiopathology ; Tumor Necrosis Factor-alpha/blood ; Walk Test
Keywords
COPD ; handgrip strength ; muscle wasting ; sarcopenia ; systemic inflammation
Abstract
BACKGROUND: Muscle wasting and chronic inflammation are predominant features of patients with COPD. Systemic inflammation is associated with an accelerated decline in lung function. In this study, the prevalence of sarcopenia and the relationships between sarcopenia and systemic inflammations in patients with stable COPD were investigated. MATERIALS AND METHODS: In a cross-sectional design, muscle strength and muscle mass were measured by handgrip strength (HGS) and bioelectrical impedance analysis in 80 patients with stable COPD. Patients (≥40 years old) diagnosed with COPD were recruited from outpatient clinics, and then COPD stages were classified. Sarcopenia was defined as the presence of both low muscle strength (by HGS) and low muscle mass (skeletal muscle mass index [SMMI]). Levels of circulating inflammatory biomarkers (IL-6 and high-sensitivity TNFα [hsTNFα]) were measured. RESULTS: Sarcopenia was prevalent in 20 (25%) patients. Patients with sarcopenia were older, had lower body mass index, and a higher percentage of cardiovascular diseases. In addition, they had significantly higher modified Medical Research Council scores and lower 6-minute walk distance than those without sarcopenia. HGS was significantly correlated with age, modified Medical Research Council score, and COPD Assessment Test scores. Both HGS and SMMI had associations with IL-6 and hsTNFα (HGS, r=-0.35, P=0.002; SMMI, r=-0.246, P=0.044) level. In multivariate analysis, old age, lower body mass index, presence of cardiovascular comorbidities, and higher hsTNFα levels were significant determinants for sarcopenia in patients with stable COPD. CONCLUSION: Sarcopenia is very common in patients with stable COPD, and is associated with more severe dyspnea-scale scores and lower exercise tolerance. Systemic inflammation could be an important contributor to sarcopenia in the stable COPD population.
Files in This Item:
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DOI
10.2147/COPD.S130790
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
김형중(Kim, Hyung Jung) ORCID logo https://orcid.org/0000-0003-2498-0683
변민광(Byun, Min Kwang) ORCID logo https://orcid.org/0000-0003-1525-1745
안철민(Ahn, Chul Min)
장준(Chang, Joon) ORCID logo https://orcid.org/0000-0003-4542-6841
조은나(Cho, Eun Na)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154498
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