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The left middle temporal gyrus in the middle of an impaired social-affective communication network in social anxiety disorder

Authors
 Je-Yeon Yun  ;  Jae-Chang Kim  ;  Jeonghun Ku  ;  Jung-Eun Shin  ;  Jae-Jin Kim  ;  Soo-Hee Choi 
Citation
 JOURNAL OF AFFECTIVE DISORDERS, Vol.214 : 53-59, 2017 
Journal Title
 JOURNAL OF AFFECTIVE DISORDERS 
ISSN
 0165-0327 
Issue Date
2017
MeSH
Adult ; Amygdala/physiopathology ; Brain/physiopathology ; Brain Mapping/methods ; Cerebral Cortex/physiopathology ; Corpus Striatum/physiopathology ; Female ; Humans ; Magnetic Resonance Imaging ; Male ; Phobia, Social/physiopathology* ; Prefrontal Cortex/physiopathology ; Temporal Lobe/physiopathology*
Keywords
Graph theory ; Intra-modular communication ; Left middle temporal gyrus ; Resting state functional connectivity ; Social anxiety disorder ; Social-affective communication network
Abstract
BACKGROUND: Previous studies on patients diagnosed with social anxiety disorder (SAD) reported changed patterns of the resting-state functional connectivity network (rs-FCN) between the prefrontal cortices and other prefrontal, amygdalar or striatal regions. Using a graph theory approach, this study explored the modularity-based community profile and patterns of inter-/intra-modular communication for the rs-FCN in SAD. METHODS: In total, for 28 SAD patients and 27 healthy controls (HC), functional magnetic resonance imaging (fMRI) data were acquired in resting-state and subjected to a graph theory analysis. RESULTS: The within-module degree z-score for a hub region [out of a total of 10 hub regions ranked using the participation coefficient] named left middle temporal gyrus was impaired in SAD compared to HC, proportional to the severity of clinician-scored and patient-reported functional impairment in SAD. LIMITATIONS: Most of participants included in this study were undergraduate students in their early-to-mid 20's. CONCLUSIONS: This study showed the importance of functional communication from the left middle temporal gyrus with other opercular-insular-subcortical regions for better objective functioning and lesser subjective disability in SAD.
Files in This Item:
T201704316.pdf Download
DOI
10.1016/j.jad.2017.01.043
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jae Jin(김재진) ORCID logo https://orcid.org/0000-0002-1395-4562
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154480
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