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The impact of production of extended-spectrum β-lactamases on the 28-day mortality rate of patients with Proteus mirabilis bacteremia in Korea

Authors
 Jin Young Ahn  ;  Hea Won Ann  ;  Yongduk Jeon  ;  Mi Young Ahn  ;  Dong Hyun Oh  ;  Yong Chan Kim  ;  Eun Jin Kim  ;  Je Eun Song  ;  In Young Jung  ;  Moo Hyun Kim  ;  Wooyoung Jeong  ;  Nam Su Ku  ;  Su Jin Jeong  ;  Jun Yong Choi  ;  Dongeun Yong  ;  Young Goo Song  ;  June Myung Kim 
Citation
 BMC INFECTIOUS DISEASES, Vol.17(1) : 327, 2017 
Journal Title
 BMC INFECTIOUS DISEASES 
Issue Date
2017
MeSH
Aged ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/therapeutic use ; Bacteremia/drug therapy ; Bacteremia/microbiology ; Bacteremia/mortality* ; Female ; Humans ; Male ; Microbial Sensitivity Tests ; Middle Aged ; Proteus Infections/drug therapy* ; Proteus Infections/metabolism ; Proteus Infections/mortality* ; Proteus mirabilis/drug effects ; Proteus mirabilis/metabolism* ; Proteus mirabilis/pathogenicity ; Republic of Korea/epidemiology ; Retrospective Studies ; Treatment Outcome ; beta-Lactamases/metabolism*
Keywords
Bacteremia ; Extended-spectrum β-lactamase ; Mortality ; Proteus Mirabilis
Abstract
BACKGROUND: The incidence of Proteus mirabilis antimicrobial resistance, especially that mediated by extended-spectrum β-lactamases (ESBLs), has increased. We investigated the impact of ESBL production on the mortality of patients with P. mirabilis bacteremia in Korea. METHODS: Patients diagnosed with P. mirabilis bacteremia between November 2005 and December 2013 at a 2000-bed tertiary care center in South Korea were included in this study. Phenotypic and molecular analyses were performed to assess ESBL expression. Characteristics and treatment outcomes were investigated among ESBL-producing and non-ESBL-producing P. mirabilis bacteremia groups. A multivariate analysis of 28-day mortality rates was performed to evaluate the independent impact of ESBLs. RESULTS: Among 62 P. mirabilis isolates from 62 patients, 14 expressed ESBLs (CTX-M, 2; TEM, 5; both, 6; other, 1), and the 28-day mortality rate of the 62 patients was 17.74%. No clinical factor was significantly associated with ESBL production. The 28-day mortality rate in the ESBL-producing group was significantly higher than that in the non-ESBL-producing group (50% vs. 8.3%, p = 0.001). A multivariate analysis showed that ESBL production (odds ratio [OR], 11.53, 95% confidence interval [CI], 2.11-63.05, p = 0.005) was independently associated with the 28-day mortality rate in patients with P. mirabilis bacteremia. CONCLUSIONS: ESBL production is significantly associated with mortality in patients with bacteremia caused by P. mirabilis. Rapid detection of ESBL expression and prompt appropriate antimicrobial therapy are required to reduce mortality caused by P. mirabilis bacteremia.
Files in This Item:
T201701381.pdf Download
DOI
10.1186/s12879-017-2431-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Ku, Nam Su(구남수) ORCID logo https://orcid.org/0000-0002-9717-4327
Kim, June Myung(김준명)
Song, Young Goo(송영구) ORCID logo https://orcid.org/0000-0002-0733-4156
Oh, Dong Hyun(오동현)
Yong, Dong Eun(용동은) ORCID logo https://orcid.org/0000-0002-1225-8477
Jeong, Su Jin(정수진) ORCID logo https://orcid.org/0000-0003-4025-4542
Jeong, Wooyong(정우용)
Jung, In Young(정인영)
Choi, Jun Yong(최준용) ORCID logo https://orcid.org/0000-0002-2775-3315
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154444
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