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Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease

Authors
 Hanna Cho  ;  Jae Yong Choi  ;  Seung Ha Lee  ;  Jae Hoon Lee  ;  Young-Chul Choi  ;  Young Hoon Ryu  ;  Myoung Sik Lee  ;  Chul Hyoung Lyoo 
Citation
 Neurobiology of Aging, Vol.53 : 103-111, 2017 
Journal Title
 Neurobiology of Aging 
ISSN
 0197-4580 
Issue Date
2017
MeSH
Aged ; Aged, 80 and over ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism* ; Alzheimer Disease/psychology* ; Cognition/physiology* ; Cognitive Dysfunction/diagnostic imaging ; Cognitive Dysfunction/metabolism ; Female ; Humans ; Male ; Memory/physiology ; Middle Aged ; Occipital Lobe/metabolism* ; Parietal Lobe/metabolism* ; Positron-Emission Tomography ; Spatial Behavior/physiology ; Verbal Behavior/physiology ; Visual Perception/physiology ; tau Proteins/metabolism*
Keywords
Alzheimer's disease ; Early onset ; Mild cognitive impairment ; Positron emission tomography ; Tau
Abstract
Early-onset Alzheimer's disease (EOAD) is characterized by greater nonmemory dysfunctions, more rapid progression, and greater hypometabolism and atrophy than late-onset AD (LOAD). We sought to investigate the differences in tau accumulation patterns between early- and late-onset patients with AD and mild cognitive impairment (MCI). In 90 patients who completed 18F-AV-1451 and 18F-florbetaben positron emission tomography scans, only 59 amyloid-positive patients (11 EOAD, 10 EOMCI, 21 LOAD, and 17 LOMCI) were included in this study. We compared cortical 18F-AV-1451 binding between each patient group and corresponding amyloid-negative age-matched controls. In contrast to no difference in cortical binding between the EOMCI and LOMCI groups, EOAD showed greater binding in the parieto-occipital cortex than LOAD. The parieto-occipital binding correlated with visuospatial dysfunction in the EOAD spectrum, whereas binding in the temporal cortex correlated with verbal memory dysfunction in the LOAD spectrum. Our findings suggest that distinct topographic distribution of tau may influence the nature of cognitive impairment in EOAD patients.
Full Text
http://www.sciencedirect.com/science/article/pii/S0197458017300349
DOI
10.1016/j.neurobiolaging.2017.01.024
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
류철형(Lyoo, Chul Hyoung) ORCID logo https://orcid.org/0000-0003-2231-672X
유영훈(Ryu, Young Hoon) ORCID logo https://orcid.org/0000-0002-9000-5563
이명식(Lee, Myung Sik) ORCID logo https://orcid.org/0000-0002-8413-1854
이승하(Lee, Seung Ha)
이재훈(Lee, Jae Hoon) ORCID logo https://orcid.org/0000-0002-9898-9886
조한나(Cho, Hanna) ORCID logo https://orcid.org/0000-0001-5936-1546
최영철(Choi, Young Chul) ORCID logo https://orcid.org/0000-0001-5525-6861
최재용(Choi, Jae Yong)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154434
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