162 165

Cited 9 times in

Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008-2011)

 Eugene Han  ;  Yong-ho Lee  ;  Byung-Wan Lee  ;  Eun Seok Kang  ;  In-Kyu Lee  ;  Bong-Soo Cha 
Journal Title
Issue Date
Absorptiometry, Photon ; Adipose Tissue/diagnostic imaging ; Adipose Tissue/physiopathology* ; Adiposity* ; Adult ; Aged ; Cardiovascular Diseases/diagnosis ; Cardiovascular Diseases/epidemiology* ; Cardiovascular ; iseases/physiopathology ; Chi-Square Distribution ; Cross-Sectional Studies ; Female ; Humans ; Logistic Models ; Lower Extremity ; Male ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/epidemiology* ; Metabolic Syndrome/physiopathology ; Middle Aged ; Multivariate Analysis ; Muscle, Skeletal/diagnostic imaging ; Muscle, Skeletal/physiopathology* ; Nutrition Surveys ; Odds Ratio ; Prognosis ; Republic of Korea/epidemiology ; Risk Assessment ; Risk Factors ; Young Adult
Cardiovascular disease risk factors ; Metabolic syndrome ; Obesity ; Risk score
BACKGROUND: Although central fat is a well-known risk factor for cardiovascular disease (CVD) and cardiometabolic disorders, the effect of other regional fats or muscle distribution on CVD risk has not been fully investigated. METHODS: This was a cross-sectional study using nationally representative samples of 15,686 subjects from the 2008-2011 Korea National Health and Nutrition Examination Survey. Individual CVD risk was evaluated in adults aged ≥20 without prior CVD, using atherosclerotic cardiovascular disease (ASCVD) risk equations according to the 2013 ACC/AHA guidelines. Body composition was assessed by dual X-ray absorptiometry. RESULTS: Ratio of leg fat to total fat (LF/TF ratio) was the most predictive for CVD among body fat or muscle distribution parameters (AUC = 0.748, 95% CI 0.741-0.755). ASCVD risk score was gradually increased with decreased LF/TF ratio (P < 0.001), and individuals whose LF/TF ratio in lowest tertile tended to belong to the high-risk (10-year risk >10%) group compared to those in the highest tertile (OR = 6.25, 95% CI 5.60-6.98). Subjects in the lowest tertile showed increased risk of cardiometabolic risk factor components including obesity, hypertension, diabetes, dyslipidemia, chronic kidney disease, and albuminuria (OR range 2.57-11.24, all P < 0.001). In addition, a higher LF/TF ratio was associated with decreased ASCVD risk, even in subjects with multiple CVD risk factors. Multiple logistic regression analyses also demonstrated this association (OR = 1.85, 95% CI 1.36-2.52). CONCLUSIONS: Among various body composition parameters, LF/TF ratio was superior in predicting higher CVD risk and a higher LF/TF ratio was independently associated with decreased risk of CVD and each cardiometabolic risk factor.
Files in This Item:
T201701301.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eun Seok(강은석) ORCID logo https://orcid.org/0000-0002-0364-4675
Lee, Byung Wan(이병완) ORCID logo https://orcid.org/0000-0002-9899-4992
Lee, Yong Ho(이용호) ORCID logo https://orcid.org/0000-0002-6219-4942
Cha, Bong Soo(차봉수) ORCID logo https://orcid.org/0000-0003-0542-2854
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.