Cited 27 times in
Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008-2011)
DC Field | Value | Language |
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dc.contributor.author | 강은석 | - |
dc.contributor.author | 이병완 | - |
dc.contributor.author | 이용호 | - |
dc.contributor.author | 차봉수 | - |
dc.date.accessioned | 2017-11-02T08:23:59Z | - |
dc.date.available | 2017-11-02T08:23:59Z | - |
dc.date.issued | 2017 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154422 | - |
dc.description.abstract | BACKGROUND: Although central fat is a well-known risk factor for cardiovascular disease (CVD) and cardiometabolic disorders, the effect of other regional fats or muscle distribution on CVD risk has not been fully investigated. METHODS: This was a cross-sectional study using nationally representative samples of 15,686 subjects from the 2008-2011 Korea National Health and Nutrition Examination Survey. Individual CVD risk was evaluated in adults aged ≥20 without prior CVD, using atherosclerotic cardiovascular disease (ASCVD) risk equations according to the 2013 ACC/AHA guidelines. Body composition was assessed by dual X-ray absorptiometry. RESULTS: Ratio of leg fat to total fat (LF/TF ratio) was the most predictive for CVD among body fat or muscle distribution parameters (AUC = 0.748, 95% CI 0.741-0.755). ASCVD risk score was gradually increased with decreased LF/TF ratio (P < 0.001), and individuals whose LF/TF ratio in lowest tertile tended to belong to the high-risk (10-year risk >10%) group compared to those in the highest tertile (OR = 6.25, 95% CI 5.60-6.98). Subjects in the lowest tertile showed increased risk of cardiometabolic risk factor components including obesity, hypertension, diabetes, dyslipidemia, chronic kidney disease, and albuminuria (OR range 2.57-11.24, all P < 0.001). In addition, a higher LF/TF ratio was associated with decreased ASCVD risk, even in subjects with multiple CVD risk factors. Multiple logistic regression analyses also demonstrated this association (OR = 1.85, 95% CI 1.36-2.52). CONCLUSIONS: Among various body composition parameters, LF/TF ratio was superior in predicting higher CVD risk and a higher LF/TF ratio was independently associated with decreased risk of CVD and each cardiometabolic risk factor. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | BioMed Central | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Absorptiometry, Photon | - |
dc.subject.MESH | Adipose Tissue/diagnostic imaging | - |
dc.subject.MESH | Adipose Tissue/physiopathology* | - |
dc.subject.MESH | Adiposity* | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Cardiovascular Diseases/diagnosis | - |
dc.subject.MESH | Cardiovascular Diseases/epidemiology* | - |
dc.subject.MESH | Cardiovascular | - |
dc.subject.MESH | iseases/physiopathology | - |
dc.subject.MESH | Chi-Square Distribution | - |
dc.subject.MESH | Cross-Sectional Studies | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Logistic Models | - |
dc.subject.MESH | Lower Extremity | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Metabolic Syndrome/diagnosis | - |
dc.subject.MESH | Metabolic Syndrome/epidemiology* | - |
dc.subject.MESH | Metabolic Syndrome/physiopathology | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Multivariate Analysis | - |
dc.subject.MESH | Muscle, Skeletal/diagnostic imaging | - |
dc.subject.MESH | Muscle, Skeletal/physiopathology* | - |
dc.subject.MESH | Nutrition Surveys | - |
dc.subject.MESH | Odds Ratio | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Republic of Korea/epidemiology | - |
dc.subject.MESH | Risk Assessment | - |
dc.subject.MESH | Risk Factors | - |
dc.subject.MESH | Young Adult | - |
dc.title | Anatomic fat depots and cardiovascular risk: a focus on the leg fat using nationwide surveys (KNHANES 2008-2011) | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Internal Medicine | - |
dc.contributor.googleauthor | Eugene Han | - |
dc.contributor.googleauthor | Yong-ho Lee | - |
dc.contributor.googleauthor | Byung-Wan Lee | - |
dc.contributor.googleauthor | Eun Seok Kang | - |
dc.contributor.googleauthor | In-Kyu Lee | - |
dc.contributor.googleauthor | Bong-Soo Cha | - |
dc.identifier.doi | 10.1186/s12933-017-0536-4 | - |
dc.contributor.localId | A02796 | - |
dc.contributor.localId | A02989 | - |
dc.contributor.localId | A03996 | - |
dc.contributor.localId | A00068 | - |
dc.relation.journalcode | J00460 | - |
dc.identifier.eissn | 1475-2840 | - |
dc.relation.journalsince | 2002~ | - |
dc.identifier.pmid | 28441953 | - |
dc.subject.keyword | Cardiovascular disease risk factors | - |
dc.subject.keyword | Metabolic syndrome | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Risk score | - |
dc.contributor.alternativeName | Kang, Eun Seok | - |
dc.contributor.alternativeName | Lee, Byung Wan | - |
dc.contributor.alternativeName | Lee, Yong Ho | - |
dc.contributor.alternativeName | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Lee, Byung Wan | - |
dc.contributor.affiliatedAuthor | Lee, Yong Ho | - |
dc.contributor.affiliatedAuthor | Cha, Bong Soo | - |
dc.contributor.affiliatedAuthor | Kang, Eun Seok | - |
dc.citation.title | Cardiovascular Diabetology | - |
dc.citation.volume | 16 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 54 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, Vol.16(1) : 54, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42997 | - |
dc.type.rims | ART | - |
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