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Bariatric Arterial Embolization with Non-spherical Polyvinyl Alcohol Particles for Ghrelin Suppression in a Swine Model

DC FieldValueLanguage
dc.contributor.author권준호-
dc.contributor.author김경민-
dc.contributor.author김만득-
dc.contributor.author김승업-
dc.contributor.author박성일-
dc.contributor.author원종윤-
dc.contributor.author이도연-
dc.contributor.author한기창-
dc.date.accessioned2017-11-02T08:21:46Z-
dc.date.available2017-11-02T08:21:46Z-
dc.date.issued2017-
dc.identifier.issn0174-1551-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154380-
dc.description.abstractPURPOSE: To evaluate the effect of bariatric arterial embolization (BAE) with non-spherical polyvinyl alcohol (PVA) particles on systemic ghrelin levels, weight change, and gastric ulceration risk in a swine model. MATERIALS AND METHODS: From March 2014 to February 2015, ten healthy swine were used in the study (mean weight 31.5 kg; range 24.0-41.5 kg). The animals were randomly assigned to two groups: the embolized group (n = 5) in which BAE was performed and the control group (n = 5). In the embolized group, BAE was performed by selectively infusing 150-250 or 50-150 μm PVA into the gastric arteries that supplied the fundus of the stomach. In the control group, a sham procedure was performed with saline infusion. Plasma ghrelin levels were prospectively obtained at baseline and every 2 weeks thereafter. Endoscopy was performed 3 weeks after BAE to see whether any gastric ulcer occurred. To determine the durability of the occluded arteries, repeated celiac trunk angiography was performed 8 weeks after BAE. Then, all the swine were killed and necropsies were performed. RESULTS: The mean post-procedure ghrelin value decreased by 370.0 pg/mL in the embolized group at week 3 (mean 536.0 ± 334.3 pg/mL) and week 5 (mean 515.0 ± 150.0 pg/mL, p < 0.05) relative to baseline (880.0 ± 559.5 pg/mL), respectively, but ghrelin levels were not significantly decreased between the embolized and control groups. There was a significant body weight change as follows: 35.1 ± 9.5 to 46.6 ± 15.7 kg and 31.8 ± 5.8 to 41.2 ± 6.6 kg at baseline and endpoint in the control and embolized groups, respectively (p < 0.05). However, the difference between groups was not significant at endpoint. In the embolized group, ulcerations were identified in three animals (60%) and the recanalization of the embolized arteries was noted on follow-up angiography in three animals (60%), respectively. CONCLUSION: BAE with PVA particles can transiently suppress ghrelin levels in embolized animals, but levels are not significantly different compared to controls. Stomach ulcerations were identified in 60% of the embolized animals.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer Verlag-
dc.relation.isPartOfCARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAngiography-
dc.subject.MESHAnimals-
dc.subject.MESHBariatrics*-
dc.subject.MESHBody Weight-
dc.subject.MESHEmbolization, Therapeutic/adverse effects-
dc.subject.MESHEmbolization, Therapeutic/methods*-
dc.subject.MESHGhrelin/blood*-
dc.subject.MESHModels, Animal-
dc.subject.MESHPolyvinyl Alcohol/administration & dosage*-
dc.subject.MESHStomach/blood supply*-
dc.subject.MESHStomach/diagnostic imaging-
dc.subject.MESHStomach/metabolism*-
dc.subject.MESHStomach Ulcer/etiology-
dc.subject.MESHSwine-
dc.titleBariatric Arterial Embolization with Non-spherical Polyvinyl Alcohol Particles for Ghrelin Suppression in a Swine Model-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorJae Min Kim-
dc.contributor.googleauthorMan-Deuk Kim-
dc.contributor.googleauthorKichang Han-
dc.contributor.googleauthorLailatul Muqmiroh-
dc.contributor.googleauthorSeung Up Kim-
dc.contributor.googleauthorGyoung Min Kim-
dc.contributor.googleauthorJoonho Kwon-
dc.contributor.googleauthorSung Il Park-
dc.contributor.googleauthorJong Yun Won-
dc.contributor.googleauthorDo Yun Lee-
dc.identifier.doi10.1007/s00270-017-1600-x-
dc.contributor.localIdA00296-
dc.contributor.localIdA00420-
dc.contributor.localIdA00654-
dc.contributor.localIdA01510-
dc.contributor.localIdA02443-
dc.contributor.localIdA02718-
dc.contributor.localIdA05062-
dc.contributor.localIdA05085-
dc.relation.journalcodeJ00459-
dc.identifier.eissn1432-086X-
dc.identifier.pmid28184958-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00270-017-1600-x-
dc.subject.keywordBariatric embolization-
dc.subject.keywordGastric artery embolization-
dc.subject.keywordGhrelin-
dc.subject.keywordObesity-
dc.subject.keywordWeight loss-
dc.contributor.alternativeNameKwon, Joon Ho-
dc.contributor.alternativeNameKim, Gyoung Min-
dc.contributor.alternativeNameKim, Man Deuk-
dc.contributor.alternativeNameKim, Seung Up-
dc.contributor.alternativeNamePark, Sung Il-
dc.contributor.alternativeNameWon, Jong Yun-
dc.contributor.alternativeNameLee, Do Yun-
dc.contributor.alternativeNameHan, Ki Chang-
dc.contributor.affiliatedAuthorKim, Gyoung Min-
dc.contributor.affiliatedAuthorKim, Man Deuk-
dc.contributor.affiliatedAuthorKim, Seung Up-
dc.contributor.affiliatedAuthorPark, Sung Il-
dc.contributor.affiliatedAuthorWon, Jong Yun-
dc.contributor.affiliatedAuthorLee, Do Yun-
dc.contributor.affiliatedAuthorHan, Ki Chang-
dc.contributor.affiliatedAuthorKwon, Joon Ho-
dc.citation.titleCardiovascular and Interventional Radiology-
dc.citation.volume40-
dc.citation.number5-
dc.citation.startPage744-
dc.citation.endPage749-
dc.identifier.bibliographicCitationCARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol.40(5) : 744-749, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers

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