Cited 15 times in
Bariatric Arterial Embolization with Non-spherical Polyvinyl Alcohol Particles for Ghrelin Suppression in a Swine Model
DC Field | Value | Language |
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dc.contributor.author | 권준호 | - |
dc.contributor.author | 김경민 | - |
dc.contributor.author | 김만득 | - |
dc.contributor.author | 김승업 | - |
dc.contributor.author | 박성일 | - |
dc.contributor.author | 원종윤 | - |
dc.contributor.author | 이도연 | - |
dc.contributor.author | 한기창 | - |
dc.date.accessioned | 2017-11-02T08:21:46Z | - |
dc.date.available | 2017-11-02T08:21:46Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0174-1551 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154380 | - |
dc.description.abstract | PURPOSE: To evaluate the effect of bariatric arterial embolization (BAE) with non-spherical polyvinyl alcohol (PVA) particles on systemic ghrelin levels, weight change, and gastric ulceration risk in a swine model. MATERIALS AND METHODS: From March 2014 to February 2015, ten healthy swine were used in the study (mean weight 31.5 kg; range 24.0-41.5 kg). The animals were randomly assigned to two groups: the embolized group (n = 5) in which BAE was performed and the control group (n = 5). In the embolized group, BAE was performed by selectively infusing 150-250 or 50-150 μm PVA into the gastric arteries that supplied the fundus of the stomach. In the control group, a sham procedure was performed with saline infusion. Plasma ghrelin levels were prospectively obtained at baseline and every 2 weeks thereafter. Endoscopy was performed 3 weeks after BAE to see whether any gastric ulcer occurred. To determine the durability of the occluded arteries, repeated celiac trunk angiography was performed 8 weeks after BAE. Then, all the swine were killed and necropsies were performed. RESULTS: The mean post-procedure ghrelin value decreased by 370.0 pg/mL in the embolized group at week 3 (mean 536.0 ± 334.3 pg/mL) and week 5 (mean 515.0 ± 150.0 pg/mL, p < 0.05) relative to baseline (880.0 ± 559.5 pg/mL), respectively, but ghrelin levels were not significantly decreased between the embolized and control groups. There was a significant body weight change as follows: 35.1 ± 9.5 to 46.6 ± 15.7 kg and 31.8 ± 5.8 to 41.2 ± 6.6 kg at baseline and endpoint in the control and embolized groups, respectively (p < 0.05). However, the difference between groups was not significant at endpoint. In the embolized group, ulcerations were identified in three animals (60%) and the recanalization of the embolized arteries was noted on follow-up angiography in three animals (60%), respectively. CONCLUSION: BAE with PVA particles can transiently suppress ghrelin levels in embolized animals, but levels are not significantly different compared to controls. Stomach ulcerations were identified in 60% of the embolized animals. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer Verlag | - |
dc.relation.isPartOf | CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Angiography | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Bariatrics* | - |
dc.subject.MESH | Body Weight | - |
dc.subject.MESH | Embolization, Therapeutic/adverse effects | - |
dc.subject.MESH | Embolization, Therapeutic/methods* | - |
dc.subject.MESH | Ghrelin/blood* | - |
dc.subject.MESH | Models, Animal | - |
dc.subject.MESH | Polyvinyl Alcohol/administration & dosage* | - |
dc.subject.MESH | Stomach/blood supply* | - |
dc.subject.MESH | Stomach/diagnostic imaging | - |
dc.subject.MESH | Stomach/metabolism* | - |
dc.subject.MESH | Stomach Ulcer/etiology | - |
dc.subject.MESH | Swine | - |
dc.title | Bariatric Arterial Embolization with Non-spherical Polyvinyl Alcohol Particles for Ghrelin Suppression in a Swine Model | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Jae Min Kim | - |
dc.contributor.googleauthor | Man-Deuk Kim | - |
dc.contributor.googleauthor | Kichang Han | - |
dc.contributor.googleauthor | Lailatul Muqmiroh | - |
dc.contributor.googleauthor | Seung Up Kim | - |
dc.contributor.googleauthor | Gyoung Min Kim | - |
dc.contributor.googleauthor | Joonho Kwon | - |
dc.contributor.googleauthor | Sung Il Park | - |
dc.contributor.googleauthor | Jong Yun Won | - |
dc.contributor.googleauthor | Do Yun Lee | - |
dc.identifier.doi | 10.1007/s00270-017-1600-x | - |
dc.contributor.localId | A00296 | - |
dc.contributor.localId | A00420 | - |
dc.contributor.localId | A00654 | - |
dc.contributor.localId | A01510 | - |
dc.contributor.localId | A02443 | - |
dc.contributor.localId | A02718 | - |
dc.contributor.localId | A05062 | - |
dc.contributor.localId | A05085 | - |
dc.relation.journalcode | J00459 | - |
dc.identifier.eissn | 1432-086X | - |
dc.identifier.pmid | 28184958 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00270-017-1600-x | - |
dc.subject.keyword | Bariatric embolization | - |
dc.subject.keyword | Gastric artery embolization | - |
dc.subject.keyword | Ghrelin | - |
dc.subject.keyword | Obesity | - |
dc.subject.keyword | Weight loss | - |
dc.contributor.alternativeName | Kwon, Joon Ho | - |
dc.contributor.alternativeName | Kim, Gyoung Min | - |
dc.contributor.alternativeName | Kim, Man Deuk | - |
dc.contributor.alternativeName | Kim, Seung Up | - |
dc.contributor.alternativeName | Park, Sung Il | - |
dc.contributor.alternativeName | Won, Jong Yun | - |
dc.contributor.alternativeName | Lee, Do Yun | - |
dc.contributor.alternativeName | Han, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kim, Gyoung Min | - |
dc.contributor.affiliatedAuthor | Kim, Man Deuk | - |
dc.contributor.affiliatedAuthor | Kim, Seung Up | - |
dc.contributor.affiliatedAuthor | Park, Sung Il | - |
dc.contributor.affiliatedAuthor | Won, Jong Yun | - |
dc.contributor.affiliatedAuthor | Lee, Do Yun | - |
dc.contributor.affiliatedAuthor | Han, Ki Chang | - |
dc.contributor.affiliatedAuthor | Kwon, Joon Ho | - |
dc.citation.title | Cardiovascular and Interventional Radiology | - |
dc.citation.volume | 40 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 744 | - |
dc.citation.endPage | 749 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, Vol.40(5) : 744-749, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42951 | - |
dc.type.rims | ART | - |
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