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간암 동물모델의 현황 및 전임상 연구에서의 활용

Other Titles
 Animal Models of Liver Cancer: Current Status and Application in Preclinical Research 
 주혜림  ;  노원상 
 Journal of Liver Cancer (대한간암학회지), Vol.17(1) : 1-14, 2017 
Journal Title
Journal of Liver Cancer(대한간암학회지)
Issue Date
Hepatocellular carcinoma ; Liver cancer animal model
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. HCC develops in various causes - Viral hepatitis infection, toxins, or other liver conditions - by activation of oncogenes and/or inactivation of tumor suppressors. Understanding of signal pathways and protein-protein interactions critical in tumor development may lead to novel treatment strategy. To evaluate the progression of HCC and effects of potential therapies, various animal models have been established. Experimental models of HCC provide valuable tools to investigate the risk factors, new treatment modalities and biologic characteristics. Subcutaneous xenograft models have been widely used in the past. However, with the advancement of in vivo imaging technology, investigators are more concerned with the orthotopic models nowadays. Genetically engineered mouse models have greatly facilitated studies of gene function in HCC development. Lately, a novel approach for stable gene expression in mouse hepatocytes by hydrodynamic injection has been developed. Each model has its own advantages and disadvantages. Therefore, selecting the optimal models based on study objectives is necessary. In this review, we highlight both the frequently used mouse models and some emerging ones with emphasis on their merits or defects, and give advices for investigators to choose a ``best-fit`` animal model in HCC research. (J Liver Cancer 2017;17:1-14)
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Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Ro, Simon Weonsang(노원상) ORCID logo https://orcid.org/0000-0003-2187-3698
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