Cited 14 times in
High-flow haemangiomas versus hypervascular hepatocellular carcinoma showing "pseudo-washout" on gadoxetic acid-enhanced hepatic MRI: value of diffusion-weighted imaging in the differential diagnosis of small lesions
DC Field | Value | Language |
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dc.contributor.author | 김주희 | - |
dc.contributor.author | 남세진 | - |
dc.contributor.author | 유정식 | - |
dc.contributor.author | 정재준 | - |
dc.contributor.author | 조은석 | - |
dc.date.accessioned | 2017-11-02T08:21:17Z | - |
dc.date.available | 2017-11-02T08:21:17Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0009-9260 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154372 | - |
dc.description.abstract | AIM: To validate the usefulness of diffusion-weighted imaging (DWI) in the differentiation of high-flow haemangiomas showing pseudo-washout appearance on gadoxetic acid-enhanced hepatic MRI from small hypervascular hepatocellular carcinomas (HCCs). MATERIALS AND METHODS: DWI (b=50, 800 s/mm2) with apparent diffusion coefficient (ADC) maps for 50 haemangiomas (6.4±2.9 mm) showing intense enhancement on arterial dominant phase imaging and hypointensity on transitional and/or hepatobiliary phase imaging during gadoxetic acid-enhanced MRI were retrospectively analysed and compared with that of 113 hypervascular HCCs (12.8±3.7 mm). In addition to measurement of mean ADC values on DWI and contrast-to-noise ratio (CNR) on corresponding T2-weighted imaging, qualitative analysis of DWI was performed for each lesion by two independent observers using a five-point scale. RESULTS: Both of mean ADC value (1.902 versus 0.997×10-3 mm2/s) and mean CNR (119.2 versus 36.9) for haemangioma were significantly larger than for HCC (p<0.001). On receiver operating characteristic (ROC) analysis, an area under the curve (AUC) of 0.995 for ADC values was significantly larger than 0.915 for CNRs (p=0.002). When the ADC value of 1.327×10-3 mm2/s was used as the threshold for the diagnosis of haemangioma, the sensitivity and specificity were 98% and 97.3%, respectively. The mean sensitivity and specificity of qualitative analysis for the differentiation of haemangioma from HCC were 92% and 99.1%, respectively. CONCLUSION: For high-flow small haemangiomas showing pseudo-washout appearance during gadoxetic acid-enhanced hepatic MRI, high b-factor DWI including an ADC map may provide additional information to enhance the confidence to exclude small hypervascular HCCs. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications Ltd | - |
dc.relation.isPartOf | CLINICAL RADIOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnostic imaging* | - |
dc.subject.MESH | Carcinoma, Hepatocellular/pathology | - |
dc.subject.MESH | Contrast Media | - |
dc.subject.MESH | Diffusion Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gadolinium DTPA* | - |
dc.subject.MESH | Hemangioma/diagnostic imaging* | - |
dc.subject.MESH | Hemangioma/pathology | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Image Enhancement/methods | - |
dc.subject.MESH | Liver Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Liver Neoplasms/pathology | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neovascularization, Pathologic/diagnostic imaging | - |
dc.subject.MESH | Neovascularization, Pathologic/pathology | - |
dc.subject.MESH | Reproducibility of Results | - |
dc.subject.MESH | Sensitivity and Specificity | - |
dc.title | High-flow haemangiomas versus hypervascular hepatocellular carcinoma showing "pseudo-washout" on gadoxetic acid-enhanced hepatic MRI: value of diffusion-weighted imaging in the differential diagnosis of small lesions | - |
dc.type | Article | - |
dc.publisher.location | England | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | S.J. Nam | - |
dc.contributor.googleauthor | J.-S. Yu | - |
dc.contributor.googleauthor | E.-S. Cho | - |
dc.contributor.googleauthor | J.H. Kim | - |
dc.contributor.googleauthor | J.-J. Chung | - |
dc.identifier.doi | 10.1016/j.crad.2016.09.020 | - |
dc.contributor.localId | A01255 | - |
dc.contributor.localId | A02500 | - |
dc.contributor.localId | A03712 | - |
dc.contributor.localId | A03881 | - |
dc.contributor.localId | A00951 | - |
dc.relation.journalcode | J00610 | - |
dc.identifier.eissn | 1365-229X | - |
dc.identifier.pmid | 27789027 | - |
dc.identifier.url | http://www.sciencedirect.com/science/article/pii/S0009926016304032 | - |
dc.contributor.alternativeName | Kim, Joo Hee | - |
dc.contributor.alternativeName | Nam, Se Jin | - |
dc.contributor.alternativeName | Yu, Jeong Sik | - |
dc.contributor.alternativeName | Chung, Jae Joon | - |
dc.contributor.alternativeName | Cho, Eun Suk | - |
dc.contributor.affiliatedAuthor | Nam, Se Jin | - |
dc.contributor.affiliatedAuthor | Yu, Jeong Sik | - |
dc.contributor.affiliatedAuthor | Chung, Jae Joon | - |
dc.contributor.affiliatedAuthor | Cho, Eun Suk | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hee | - |
dc.citation.title | Clinical Radiology | - |
dc.citation.volume | 72 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 247 | - |
dc.citation.endPage | 254 | - |
dc.identifier.bibliographicCitation | CLINICAL RADIOLOGY, Vol.72(3) : 247-254, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42942 | - |
dc.type.rims | ART | - |
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