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Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease

Authors
 William C. Kreisl  ;  Chul Hyoung Lyoo  ;  Jeih-San Liow  ;  Joseph Snow  ;  Emily Page  ;  Kimberly J. Jenko  ;  Cheryl L. Morse  ;  Sami S. Zoghbi  ;  Victor W. Pike  ;  R. Scott Turner  ;  Robert B. Innis 
Citation
 Neurobiology of Aging, Vol.51 : 132-140, 2017 
Journal Title
 Neurobiology of Aging 
ISSN
 0197-4580 
Issue Date
2017
MeSH
Aged ; Alzheimer Disease/diagnostic imaging ; Alzheimer Disease/metabolism* ; Alzheimer Disease/pathology* ; Amyloid/metabolism ; Atrophy ; Female ; Glucose/metabolism ; Humans ; Male ; Microglia/pathology ; Middle Aged ; Nerve Degeneration ; Occipital Lobe/diagnostic imaging ; Occipital Lobe/metabolism* ; Occipital Lobe/pathology* ; Positron-Emission Tomography ; Protein Binding ; Receptors, GABA/metabolism*
Keywords
Alzheimer's disease ; Neuroinflammation ; PET imaging
Abstract
We sought to determine whether patients with posterior cortical atrophy (PCA) demonstrate a pattern of binding to translocator protein 18 kDa, a marker of microglial activation, that is distinct from that in patients with amnestic presentation of Alzheimer's disease (AD). Eleven PCA patients, 11 amnestic AD patients, and 15 age-matched controls underwent positron emission tomography with 11C-PBR28 to measure translocator protein 18 kDa. PCA patients showed greater 11C-PBR28 binding than controls in occipital, posterior parietal, and temporal regions. In contrast, amnestic AD patients showed greater 11C-PBR28 binding in inferior and medial temporal cortex. Increased 11C-PBR28 binding overlapped with reduced cortical volume for both PCA and amnestic AD patients, and with areas of reduced glucose metabolism in PCA patients. While both patient groups showed diffuse amyloid binding, PCA patients showed greater binding than amnestic AD patients in bilateral occipital cortex. These results suggest that microglial activation is closely associated with neurodegeneration across different subtypes of AD.
Full Text
http://www.sciencedirect.com/science/article/pii/S0197458016303128
DOI
10.1016/j.neurobiolaging.2016.12.006
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실)
Yonsei Authors
류철형(Lyoo, Chul Hyoung)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154369
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