0 496

Cited 37 times in

Distinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease

DC Field Value Language
dc.contributor.author류철형-
dc.date.accessioned2017-11-02T08:21:11Z-
dc.date.available2017-11-02T08:21:11Z-
dc.date.issued2017-
dc.identifier.issn0197-4580-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154369-
dc.description.abstractWe sought to determine whether patients with posterior cortical atrophy (PCA) demonstrate a pattern of binding to translocator protein 18 kDa, a marker of microglial activation, that is distinct from that in patients with amnestic presentation of Alzheimer's disease (AD). Eleven PCA patients, 11 amnestic AD patients, and 15 age-matched controls underwent positron emission tomography with 11C-PBR28 to measure translocator protein 18 kDa. PCA patients showed greater 11C-PBR28 binding than controls in occipital, posterior parietal, and temporal regions. In contrast, amnestic AD patients showed greater 11C-PBR28 binding in inferior and medial temporal cortex. Increased 11C-PBR28 binding overlapped with reduced cortical volume for both PCA and amnestic AD patients, and with areas of reduced glucose metabolism in PCA patients. While both patient groups showed diffuse amyloid binding, PCA patients showed greater binding than amnestic AD patients in bilateral occipital cortex. These results suggest that microglial activation is closely associated with neurodegeneration across different subtypes of AD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfNEUROBIOLOGY OF AGING-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAlzheimer Disease/diagnostic imaging-
dc.subject.MESHAlzheimer Disease/metabolism*-
dc.subject.MESHAlzheimer Disease/pathology*-
dc.subject.MESHAmyloid/metabolism-
dc.subject.MESHAtrophy-
dc.subject.MESHFemale-
dc.subject.MESHGlucose/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHMale-
dc.subject.MESHMicroglia/pathology-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNerve Degeneration-
dc.subject.MESHOccipital Lobe/diagnostic imaging-
dc.subject.MESHOccipital Lobe/metabolism*-
dc.subject.MESHOccipital Lobe/pathology*-
dc.subject.MESHPositron-Emission Tomography-
dc.subject.MESHProtein Binding-
dc.subject.MESHReceptors, GABA/metabolism*-
dc.titleDistinct patterns of increased translocator protein in posterior cortical atrophy and amnestic Alzheimer's disease-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorWilliam C. Kreisl-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.contributor.googleauthorJeih-San Liow-
dc.contributor.googleauthorJoseph Snow-
dc.contributor.googleauthorEmily Page-
dc.contributor.googleauthorKimberly J. Jenko-
dc.contributor.googleauthorCheryl L. Morse-
dc.contributor.googleauthorSami S. Zoghbi-
dc.contributor.googleauthorVictor W. Pike-
dc.contributor.googleauthorR. Scott Turner-
dc.contributor.googleauthorRobert B. Innis-
dc.identifier.doi10.1016/j.neurobiolaging.2016.12.006-
dc.contributor.localIdA01333-
dc.relation.journalcodeJ02322-
dc.identifier.eissn1558-1497-
dc.identifier.pmid28068564-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0197458016303128-
dc.subject.keywordAlzheimer's disease-
dc.subject.keywordNeuroinflammation-
dc.subject.keywordPET imaging-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.citation.titleNeurobiology of Aging-
dc.citation.volume51-
dc.citation.startPage132-
dc.citation.endPage140-
dc.identifier.bibliographicCitationNEUROBIOLOGY OF AGING, Vol.51 : 132-140, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42939-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.