Cited 19 times in
Usefulness of the Delta Neutrophil Index as a Promising Prognostic Marker of Acute Cholangitis in Emergency Departments
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 고동률 | - |
dc.contributor.author | 공태영 | - |
dc.contributor.author | 김현철 | - |
dc.contributor.author | 박인철 | - |
dc.contributor.author | 유제성 | - |
dc.contributor.author | 정성필 | - |
dc.contributor.author | 주영선 | - |
dc.contributor.author | 홍정화 | - |
dc.date.accessioned | 2017-11-02T08:18:14Z | - |
dc.date.available | 2017-11-02T08:18:14Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 1073-2322 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154315 | - |
dc.description.abstract | PURPOSE: Recent technological advances have led to analyses of the delta neutrophil index (DNI), which reflects the fraction of circulating immature granulocytes, using specific automated blood cell analyzers. We evaluated the significance of the DNI as a prognostic marker for early severity in patients with acute cholangitis. METHODS: We retrospectively analyzed patients initially diagnosed with acute cholangitis at emergency department admission, followed by diagnostic confirmation, during a set period. The DNI was determined on each day of hospitalization. Clinical outcomes were the incidence of shock requiring vasopressor/inotrope and 28-day mortality. RESULTS: We included 461 patients who met our inclusion criteria. According to multivariate Cox proportional hazard models, higher DNI at admission (hazard ratio [HR]: 1.102; 95% confidence interval [CI]: 1.053-1.153; P < 0.001), day 1 (HR: 1.069; 95% CI: 1.018-1.122; P = 0.008), and day 2 (HR: 1.118; 95% CI: 1.053-1.186; P < 0.001) were significant risk factors for 28-day mortality. Among patients with acute cholangitis, a DNI > 4.9% at admission (HR: 5.632; 95% CI: 1.977-16.045; P = 0.001) and day 1 (HR, 9.973; 95% CI: 2.666-37.302; P < 0.001) and higher DNI ( > 2.5%) on day 2 (HR, 16.942; 95% CI: 2.15-133.496; P = 0.007) were associated with increased 28-day mortality. CONCLUSION: Higher DNI levels are predictive markers of hemodynamic instability and 28-day mortality in patients with acute cholangitis. The accuracy of DNI for predicting hemodynamic instability and 28-day mortality is superior to that of other parameters. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Lippincott Williams & Wilkins | - |
dc.relation.isPartOf | SHOCK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Biomarkers/blood* | - |
dc.subject.MESH | Cholangitis/blood* | - |
dc.subject.MESH | Cholangitis/pathology* | - |
dc.subject.MESH | Emergency Service, Hospital/statistics & numerical data | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Neutrophils/physiology* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Proportional Hazards Models | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Risk Factors | - |
dc.title | Usefulness of the Delta Neutrophil Index as a Promising Prognostic Marker of Acute Cholangitis in Emergency Departments | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Emergency Medicine | - |
dc.contributor.googleauthor | Hyunchul Kim | - |
dc.contributor.googleauthor | Taeyoung Kong | - |
dc.contributor.googleauthor | Sung Phil Chung | - |
dc.contributor.googleauthor | Jung Hwa Hong | - |
dc.contributor.googleauthor | Jong Wook Lee | - |
dc.contributor.googleauthor | Youngseon Joo | - |
dc.contributor.googleauthor | Dong Ryul Ko | - |
dc.contributor.googleauthor | Je Sung You | - |
dc.contributor.googleauthor | Incheol Park | - |
dc.identifier.doi | 10.1097/SHK.0000000000000722 | - |
dc.contributor.localId | A00162 | - |
dc.contributor.localId | A05114 | - |
dc.contributor.localId | A01628 | - |
dc.contributor.localId | A02507 | - |
dc.contributor.localId | A03625 | - |
dc.contributor.localId | A03955 | - |
dc.contributor.localId | A04433 | - |
dc.contributor.localId | A00113 | - |
dc.relation.journalcode | J02658 | - |
dc.identifier.eissn | 1540-0514 | - |
dc.identifier.pmid | 27559701 | - |
dc.identifier.url | http://www.ingentaconnect.com/content/wk/shk/2017/00000047/00000003/art00007 | - |
dc.subject.keyword | Acute cholangitis | - |
dc.subject.keyword | admission | - |
dc.subject.keyword | biliary tract | - |
dc.subject.keyword | delta neutrophil index | - |
dc.subject.keyword | immature granulocyte | - |
dc.subject.keyword | mortality | - |
dc.subject.keyword | shock | - |
dc.contributor.alternativeName | Ko, Dong Ryul | - |
dc.contributor.alternativeName | Kong, Tae Young | - |
dc.contributor.alternativeName | Kim, Hyun Chul | - |
dc.contributor.alternativeName | Park, In Cheol | - |
dc.contributor.alternativeName | You, Je Sung | - |
dc.contributor.alternativeName | Chung, Sung Pil | - |
dc.contributor.alternativeName | Joo, Young Seon | - |
dc.contributor.alternativeName | Hong, Jung Hwa | - |
dc.contributor.affiliatedAuthor | Kong, Tae Young | - |
dc.contributor.affiliatedAuthor | Kim, Hyun Chul | - |
dc.contributor.affiliatedAuthor | Park, In Cheol | - |
dc.contributor.affiliatedAuthor | You, Je Sung | - |
dc.contributor.affiliatedAuthor | Chung, Sung Pil | - |
dc.contributor.affiliatedAuthor | Joo, Young Seon | - |
dc.contributor.affiliatedAuthor | Hong, Jung Hwa | - |
dc.contributor.affiliatedAuthor | Ko, Dong Ryul | - |
dc.citation.title | Shock | - |
dc.citation.volume | 47 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 303 | - |
dc.citation.endPage | 312 | - |
dc.identifier.bibliographicCitation | SHOCK, Vol.47(3) : 303-312, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 42287 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.