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Interleukin-33 regulates intestinal inflammation by modulating macrophages in inflammatory bowel disease

Authors
 Dong Hyuk Seo  ;  Xiumei Che  ;  Min Seob Kwak  ;  Soochan Kim  ;  Jae Hyeon Kim  ;  Hyun Woo Ma  ;  Da Hye Kim  ;  Tae Il Kim  ;  Won Ho Kim  ;  Seung Won Kim  ;  Jae Hee Cheon 
Citation
 Scientific Reports, Vol.7(1) : 851-851, 2017 
Journal Title
 Scientific Reports 
ISSN
 2045-2322 
Issue Date
2017
Abstract
Interleukin 33 (IL-33) that signals through the ST2 receptor has emerged as a critical modulator in several inflammatory disorders, including inflammatory bowel disease (IBD). However, the precise mechanisms by which IL-33 modulates IBD are controversial. The aim of this study was thus to clarify the role of IL-33 in IBD. The plasma levels of IL-33 were significantly decreased, but soluble ST2 levels were increased in patients with IBD compared to healthy individuals. Moreover, IL-33 restored goblet cell numbers and induced macrophage switching from the M1 to the M2 phenotype. These effects were sufficient to ameliorate colitis in dextran sodium sulfate, trinitrobenzene sulfonic acid, and peritoneal cavity cell transfer models. IL-33 facilitated goblet cell restoration via modulating macrophages toward the M2 phenotype. In addition, wound healing was significantly faster in IL-33-treated human monocyte-derived macrophages than in control cells, which could be attributed to increased polarisation into M2 macrophages. We found that patients with IBD show decreased serum levels of IL-33 compared with healthy individuals and that IL-33 can attenuate colitis and aid tissue repair in mice. The mechanism by which IL-33 exerts these effects appears to involve the stimulation of differentiation of goblet cells and M2 macrophages.
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DOI
10.1038/s41598-017-00840-2
Appears in Collections:
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실)
1. Journal Papers (연구논문) > 1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부)
Yonsei Authors
김승원(Kim, Seung Won)
김원호(Kim, Won Ho)
김태일(Kim, Tae Il) ORCID logo https://orcid.org/0000-0003-4807-890X
천재희(Cheon, Jae Hee) ORCID logo https://orcid.org/0000-0002-2282-8904
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154231
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