102 122

Cited 0 times in

Decreased potency of fimasartan in liver cirrhosis was quantified using mixed-effects analysis

Authors
 Choon OK Kim  ;  Sangil Jeon  ;  Seunghoon Han  ;  Taegon Hong  ;  Min Soo Park  ;  Young-Ran Yoon  ;  Dong-Seok Yim 
Citation
 Translational and Clinical Pharmacology, Vol.25(1) : 43-51, 2017 
Journal Title
 Translational and Clinical Pharmacology 
ISSN
 2289-0882 
Issue Date
2017
Keywords
Population PK-PD ; modeling ; NONMEM ; hepatic impairment ; fimasartan ; blood pressure
Abstract
Fimasartan is a nonpeptide angiotensin II receptor blocker. In a previous study that compared the pharmacokinetics (PK) of fimasartan between patients with hepatic impairment (cirrhosis) and healthy subjects, the exposure to fimasartan was found to be higher in patients, but the decrease of blood pressure (BP) was not clinically significant in those with moderate hepatic impairment. The aims of this study were to develop a population PK-pharmacodynamic (PD) model of fimasartan and to evaluate the effect of hepatic function on BP reduction by fimasartan using previously published data. A 2-compartment linear model with mixed zero-order absorption followed by first-order absorption with a lag time adequately described fimasartan PK, and the effect of fimasartan on BP changes was well explained by the inhibitory sigmoid function in the turnover PK-PD model overlaid with a model of circadian rhythm (NONMEM version 7.2). According to our PD model, the lower BP responses in hepatic impairment were the result of the increased fimasartan EC50 in patients, rather than from a saturation of effect. This is congruent with the reported pathophysiological change of increased plasma ACE and renin activity in hepatic cirrhosis.
Files in This Item:
T201702051.pdf Download
DOI
10.12793/tcp.2017.25.1.43
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Choon Ok(김춘옥) ORCID logo https://orcid.org/0000-0002-2319-1108
Park, Min Soo(박민수) ORCID logo https://orcid.org/0000-0002-4395-9938
Hong, Tae Gon(홍태곤) ORCID logo https://orcid.org/0000-0001-7490-0085
Export
RIS (EndNote)
XLS (Excel)
XML
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154221
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse