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Morning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes

 So Ra Kim  ;  Yong-ho Lee  ;  Sang-Guk Lee  ;  Sun Hee Lee  ;  Eun Seok Kang  ;  Bong-Soo Cha  ;  Hyun Chul Lee  ;  Jeong-Ho Kim  ;  Byung-Wan Lee 
 Annals of Laboratory Medicine, Vol.37(1) : 9-17, 2017 
Journal Title
 Annals of Laboratory Medicine 
Issue Date
Adult ; Aged ; Blood Glucose/analysis ; Creatinine/urine* ; Cross-Sectional Studies ; Diabetes Mellitus, Type 2/pathology* ; Female ; Glucose/analysis* ; Glucose/metabolism ; Humans ; Linear Models ; Male ; Middle Aged ; Prospective Studies ; Urinalysis
Type 2 diabetes mellitus ; Urinary glucose excretion ; Urinary glucose-to-creatinine ratio
Background : With the advent of sodium glucose co-transporter 2 inhibitors to control glucose and treat diabetes, laboratory data aided by either timed or spot glucose levels in the urine could be used as an alternative marker of drug response. The aim of this study was to assess the agreement between overnight urinary glucose excretion (UGE) and morning spot urinary glucose-to-creatinine ratio (UGCR). Methods : In this prospective cross-sectional study, we enrolled a total of 215 participants with either normal glucose tolerance (NGT), pre-diabetes, or type 2 diabetes mellitus (T2DM). To exclude external factors such as food intake and physical activity, urine samples collected overnight at an 8-hr interval and the first-voided morning spot urine were collected and compared. Results : The median values of overnight 8-hr UGE in participants with NGT (N=14), pre-diabetes (N=41), and T2DM (N=160) were 35.0 mg, 35.6 mg, and 653.4 mg, respectively. In participants with T2DM, the median values of overnight 8-hr UGCR and first-voided morning spot UGCR (M-UGCR) were 1.37 mg/mg and 0.16 mg/mg, respectively. Quantitative analyses using an intraclass correlation coefficient (ICC) demonstrated a good reliability of measurement of the overnight 8-hr UGCR and M-UGCR (ICC=0.943, P<0.001). The M-UGCR was also significantly related to the overnight 8-hr UGE (r=0.828, P<0.001). Conclusions : M-UGCR and overnight 8-hr UGCR showed good agreement, suggesting that M-UGCR be used as a simple index for estimating overnight amounts of UGE in patients with T2DM.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
강은석(Kang, Eun Seok) ORCID logo https://orcid.org/0000-0002-0364-4675
김소라(Kim, So Ra)
김정호(Kim, Jeong Ho) ORCID logo https://orcid.org/0000-0003-2479-0548
이병완(Lee, Byung Wan) ORCID logo https://orcid.org/0000-0002-9899-4992
이상국(Lee, Sang-Guk) ORCID logo https://orcid.org/0000-0003-3862-3660
이용호(Lee, Yong Ho) ORCID logo https://orcid.org/0000-0002-6219-4942
차봉수(Cha, Bong Soo) ORCID logo https://orcid.org/0000-0003-0542-2854
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