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Morning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes

DC Field Value Language
dc.contributor.author강은석-
dc.contributor.author김소라-
dc.contributor.author김정호-
dc.contributor.author이병완-
dc.contributor.author이상국-
dc.contributor.author이용호-
dc.contributor.author차봉수-
dc.date.accessioned2017-11-02T08:09:30Z-
dc.date.available2017-11-02T08:09:30Z-
dc.date.issued2017-
dc.identifier.issn2234-3806-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154145-
dc.description.abstractBackground : With the advent of sodium glucose co-transporter 2 inhibitors to control glucose and treat diabetes, laboratory data aided by either timed or spot glucose levels in the urine could be used as an alternative marker of drug response. The aim of this study was to assess the agreement between overnight urinary glucose excretion (UGE) and morning spot urinary glucose-to-creatinine ratio (UGCR). Methods : In this prospective cross-sectional study, we enrolled a total of 215 participants with either normal glucose tolerance (NGT), pre-diabetes, or type 2 diabetes mellitus (T2DM). To exclude external factors such as food intake and physical activity, urine samples collected overnight at an 8-hr interval and the first-voided morning spot urine were collected and compared. Results : The median values of overnight 8-hr UGE in participants with NGT (N=14), pre-diabetes (N=41), and T2DM (N=160) were 35.0 mg, 35.6 mg, and 653.4 mg, respectively. In participants with T2DM, the median values of overnight 8-hr UGCR and first-voided morning spot UGCR (M-UGCR) were 1.37 mg/mg and 0.16 mg/mg, respectively. Quantitative analyses using an intraclass correlation coefficient (ICC) demonstrated a good reliability of measurement of the overnight 8-hr UGCR and M-UGCR (ICC=0.943, P<0.001). The M-UGCR was also significantly related to the overnight 8-hr UGE (r=0.828, P<0.001). Conclusions : M-UGCR and overnight 8-hr UGCR showed good agreement, suggesting that M-UGCR be used as a simple index for estimating overnight amounts of UGE in patients with T2DM.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherKorean Society for Laboratory Medicine-
dc.relation.isPartOfANNALS OF LABORATORY MEDICINE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBlood Glucose/analysis-
dc.subject.MESHCreatinine/urine*-
dc.subject.MESHCross-Sectional Studies-
dc.subject.MESHDiabetes Mellitus, Type 2/pathology*-
dc.subject.MESHFemale-
dc.subject.MESHGlucose/analysis*-
dc.subject.MESHGlucose/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHLinear Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHProspective Studies-
dc.subject.MESHUrinalysis-
dc.titleMorning Spot Urine Glucose-to-Creatinine Ratios Predict Overnight Urinary Glucose Excretion in Patients With Type 2 Diabetes-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Internal Medicine-
dc.contributor.googleauthorSo Ra Kim-
dc.contributor.googleauthorYong-ho Lee-
dc.contributor.googleauthorSang-Guk Lee-
dc.contributor.googleauthorSun Hee Lee-
dc.contributor.googleauthorEun Seok Kang-
dc.contributor.googleauthorBong-Soo Cha-
dc.contributor.googleauthorHyun Chul Lee-
dc.contributor.googleauthorJeong-Ho Kim-
dc.contributor.googleauthorByung-Wan Lee-
dc.identifier.doi10.3343/alm.2017.37.1.9-
dc.contributor.localIdA00612-
dc.contributor.localIdA00903-
dc.contributor.localIdA02796-
dc.contributor.localIdA02810-
dc.contributor.localIdA02989-
dc.contributor.localIdA03996-
dc.contributor.localIdA00068-
dc.relation.journalcodeJ00164-
dc.identifier.eissn2234-3814-
dc.relation.journalsince2012~-
dc.identifier.pmid27834060-
dc.relation.journalbefore~2011 Korean Journal of Laboratory Medicine (대한진단검사의학회지)-
dc.subject.keywordType 2 diabetes mellitus-
dc.subject.keywordUrinary glucose excretion-
dc.subject.keywordUrinary glucose-to-creatinine ratio-
dc.contributor.alternativeNameKang, Eun Seok-
dc.contributor.alternativeNameKim, So Ra-
dc.contributor.alternativeNameKim, Jeong Ho-
dc.contributor.alternativeNameLee, Byung Wan-
dc.contributor.alternativeNameLee, Sang Guk-
dc.contributor.alternativeNameLee, Yong Ho-
dc.contributor.alternativeNameCha, Bong Soo-
dc.contributor.affiliatedAuthorKim, So Ra-
dc.contributor.affiliatedAuthorKim, Jeong Ho-
dc.contributor.affiliatedAuthorLee, Byung Wan-
dc.contributor.affiliatedAuthorLee, Sang Guk-
dc.contributor.affiliatedAuthorLee, Yong Ho-
dc.contributor.affiliatedAuthorCha, Bong Soo-
dc.contributor.affiliatedAuthorKang, Eun Seok-
dc.citation.titleAnnals of Laboratory Medicine-
dc.citation.volume37-
dc.citation.number1-
dc.citation.startPage9-
dc.citation.endPage17-
dc.identifier.bibliographicCitationANNALS OF LABORATORY MEDICINE, Vol.37(1) : 9-17, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42107-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Hospital Medicine (입원의학과) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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