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A simple scoring model for advanced colorectal neoplasm in asymptomatic subjects aged 40-49 years

 Yoo Mi Par  ;  Hee Sun Kim  ;  Jae Jun Par  ;  Su Jung Baik  ;  Young Hoon Youn  ;  Jie-Hyun Kim  ;  Hyojin Park 
 BMC GASTROENTEROLOGY, Vol.17(1) : 7, 2017 
Journal Title
Issue Date
Adult ; Age Factors ; Area Under Curve ; Asymptomatic Diseases* ; Colonoscopy ; Colorectal Neoplasms/diagnosis* ; Colorectal Neoplasms/epidemiology ; Colorectal Neoplasms/etiology ; Decision Support Techniques* ; Early Detection of Cancer/methods* ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Predictive Value of Tests ; Prevalence ; Retrospective Studies ; Risk Assessment ; Risk Factors ; Sensitivity and Specificity ; Sex Factors
Adenoma ; Colonoscopy ; Colorectal neoplasm ; Risk assessment ; Screening
BACKGROUND: Limited data are available for advanced colorectal neoplasm in asymptomatic individuals aged 40-49 years. We aimed to identify risk factors and develop a simple prediction model for advanced colorectal neoplasm in these persons. METHODS: Clinical data were collected on 2781 asymptomatic subjects aged 40-49 years who underwent colonoscopy for routine health examination. Subjects were randomly allocated to a development or validation set. Logistic regression analysis was used to determine predictors of advanced colorectal neoplasm. RESULTS: The prevalence of overall and advanced colorectal neoplasm was 20.2 and 2.5% respectively. Older age (45-49 years), male sex, positive serology of Helicobacter pylori, and high triglyceride and low high-density lipoprotein (HDL) levels were independently associated with an increased risk of advanced colorectal neoplasm. BMI (body mass index) was not significant in multivariable analysis. We developed a simple scoring model for advanced colorectal neoplasm (range 0-9). A cutoff of ≥4 defined 43% of subjects as high risk for advanced colorectal neoplasm (sensitivity, 79%; specificity, 58%; area under the receiver operating curve = 0.72) in the validation datasets. CONCLUSION: Older age (45-49 years), male sex, positive serology of H. pylori, high triglyceride level, and low HDL level were identified as independent risk factors for advanced colorectal neoplasm.
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1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jie-Hyun(김지현) ORCID logo https://orcid.org/0000-0002-9198-3326
Park, Yoo Mi(박유미) ORCID logo https://orcid.org/0000-0002-3642-7300
Park, Jae Jun(박재준)
Park, Hyo Jin(박효진) ORCID logo https://orcid.org/0000-0003-4814-8330
Baik, Su Jung(백수정) ORCID logo https://orcid.org/0000-0002-3790-7701
Youn, Young Hoon(윤영훈) ORCID logo https://orcid.org/0000-0002-0071-229X
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