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Factors associated with improvement or decline in cognitive function after an ischemic stroke in Korea: the Korean stroke cohort for functioning and rehabilitation (KOSCO) study

Authors
 Jin A. Yoon  ;  Deog Young Kim  ;  Min Kyun Sohn  ;  Jongmin Lee  ;  Sam-Gyu Lee  ;  Yang-Soo Lee  ;  Eun Young Han  ;  Min Cheol Joo  ;  Gyung-Jae Oh  ;  Junhee Han  ;  Minsu Park  ;  Kyung Pil Park  ;  Kyung-Ha Noh  ;  Won Hyuk Chang  ;  Yong-Il Shin  ;  Yun-Hee Kim 
Citation
 BMC Neurology, Vol.17(9) : 1-12, 2017 
Journal Title
 BMC Neurology 
Issue Date
2017
MeSH
Aged ; Aged, 80 and over ; Cognition* ; Cognition Disorders/diagnosis ; Cognition Disorders/etiology* ; Cohort Studies ; Female ; Humans ; Male ; Middle Aged ; Neuropsychological Tests ; Prospective Studies ; Republic of Korea ; Stroke/complications* ; Stroke/epidemiology
Keywords
Cognition ; Inverter ; Ischemic stroke ; Reverter ; Risk factors
Abstract
BACKGROUND: We conducted a prospective cohort study to investigate prevalence of poststroke cognitive impairment at 3 and 12 months after stroke onset and identify clinical and demographic factors associated with improvement or decline in cognitive function between 3 months and 12 months. METHODS: We analyzed the cognitive assessments of total patients and patients older than 65 years separately. All patients with an ischemic stroke were divided into normal cognitive group (NCG) and impaired cognition group (ICG) by using a cutoff score on the Korean Mini-Mental State Examination (K-MMSE). Patients were additionally classified into 3 subgroups according to the changes in their K-MMSE scores between 3 and 12 months: Stable group with K-MMSE scores changes ranging from -2 to +2 points (-2 ≤ △MMSE ≤ +2); converter group with increase more than 3 points (3 ≤ △MMSE); and reverter group with decrease more than 3 points (-3 ≤ △MMSE). We also analyzed factors affecting cognitive change from 3 months to 12 months among the 3 groups including baseline medical record, stroke and treatment characteristics, and various functional assessments after 3 months. RESULTS: This study included 2,625 patients with the first time ischemic stroke. Among these patients, 1,735 (66.1%) were classified as NCG, while 890 patients (33.9%) were belonged to the ICG at 3 month. Within the NCG, 1,460 patients (82.4%) were stable group, 93 patients (5.4%) were converter group, and 212 patients (12.2%) were reverter group at 12 months onset. Within the ICG group, 472 patients (53.0%) were stable group, 321 patients (36.1%) were converter group, and 97 patients (10.9%) were reverter group. When different factors were investigated, the three subgroups in NCG and ICG showed significant different factors affecting cognitive function from 3 to 12 month. CONCLUSIONS: The prevalence of cognitive impairment showed difference between 3,12 months. To analyze the cognitive change from 3 month to 12 month, the proportion stable group was dominant in NCG and converter group was higher in ICG. By investigating the influencing factors from each group, we were able to identify the predictors including the age factor.
Files in This Item:
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DOI
10.1186/s12883-016-0780-3
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Rehabilitation Medicine (재활의학교실) > 1. Journal Papers
Yonsei Authors
김덕용(Kim, Deog Young) ORCID logo https://orcid.org/0000-0001-7622-6311
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154106
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