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Anti-adhesive effect of solid mixture of sodium hyaluronate/carboxymethylcellulose in murine nasal cavities

Authors
 Eun Jung Lee  ;  Hye Jin Hwang  ;  Chan Min Jung  ;  Min Ki Kim  ;  Kyung-Su Kim 
Citation
 EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, Vol.274(1) : 181-188, 2017 
Journal Title
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
ISSN
 0937-4477 
Issue Date
2017
MeSH
Animals ; Carboxymethylcellulose Sodium/pharmacology* ; Endoscopy ; Fibrosis/prevention & control ; Hyaluronic Acid/pharmacology* ; Models, Animal ; Nasal Cavity/surgery* ; Nasal Mucosa/injuries ; Nasal Mucosa/pathology ; Nasal Mucosa/surgery ; Rats, Sprague-Dawley ; Tissue Adhesions/prevention & control* ; Viscosupplements/pharmacology*
Keywords
Adhesion ; Endoscopic sinus surgery ; Mucosal injury ; Murine model ; Solid mixture of sodium hyaluronate/carboxymethylcellulose
Abstract
The purpose of the study was to evaluate the effect of a solid mixture of sodium hyaluronate and carboxymethylcellulose (S-HA/CMC) for the prevention of adhesions after iatrogenic mucosal injury in murine nasal cavities. We introduced iatrogenic adhesions into the bilateral nasal cavities of 20 male Sprague-Dawley rats. S-HA/CMC was applied to the left nasal cavity, while no packing was placed in the right nasal cavity as a control. At 1, 2, and 4 weeks post-procedure, we examined the number of adhesions, the ratio of the longest cross-sectional length of adhesion to septal cartilage length (RAC), and the degree of fibrosis. S-HA/CMC significantly reduced the number of adhesions when compared to the control group in total (p = 0.031), but not at each individual time point. The S-HA/CMC group showed significantly shorter RAC than the control group in total (p = 0.044), but not at each individual time point. The total fibrosis score was less severe in the S-HA/CMC group than in the control group (p < 0.001), with a significant difference between the two groups at the second week (p = 0.001). Therefore, in an animal model, S-HA/CMC can prevent post-injury mucosal adhesions suggesting a potential for clinical applications in endoscopic sinus surgery. Further clinical trials are needed to determine the safety and efficacy of S-HA/CMC as nasal packing after endoscopic sinus surgery.
Full Text
https://link.springer.com/article/10.1007%2Fs00405-016-4186-z
DOI
10.1007/s00405-016-4186-z
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Su(김경수) ORCID logo https://orcid.org/0000-0003-1460-0640
Lee, Eun Jung(이은정) ORCID logo https://orcid.org/0000-0002-0454-4510
Jung, Chan Min(정찬민) ORCID logo https://orcid.org/0000-0002-1445-2564
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154100
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