Cited 2 times in
Anti-adhesive effect of solid mixture of sodium hyaluronate/carboxymethylcellulose in murine nasal cavities
DC Field | Value | Language |
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dc.contributor.author | 김경수 | - |
dc.contributor.author | 이은정 | - |
dc.contributor.author | 정찬민 | - |
dc.date.accessioned | 2017-11-02T08:07:11Z | - |
dc.date.available | 2017-11-02T08:07:11Z | - |
dc.date.issued | 2017 | - |
dc.identifier.issn | 0937-4477 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/154100 | - |
dc.description.abstract | The purpose of the study was to evaluate the effect of a solid mixture of sodium hyaluronate and carboxymethylcellulose (S-HA/CMC) for the prevention of adhesions after iatrogenic mucosal injury in murine nasal cavities. We introduced iatrogenic adhesions into the bilateral nasal cavities of 20 male Sprague-Dawley rats. S-HA/CMC was applied to the left nasal cavity, while no packing was placed in the right nasal cavity as a control. At 1, 2, and 4 weeks post-procedure, we examined the number of adhesions, the ratio of the longest cross-sectional length of adhesion to septal cartilage length (RAC), and the degree of fibrosis. S-HA/CMC significantly reduced the number of adhesions when compared to the control group in total (p = 0.031), but not at each individual time point. The S-HA/CMC group showed significantly shorter RAC than the control group in total (p = 0.044), but not at each individual time point. The total fibrosis score was less severe in the S-HA/CMC group than in the control group (p < 0.001), with a significant difference between the two groups at the second week (p = 0.001). Therefore, in an animal model, S-HA/CMC can prevent post-injury mucosal adhesions suggesting a potential for clinical applications in endoscopic sinus surgery. Further clinical trials are needed to determine the safety and efficacy of S-HA/CMC as nasal packing after endoscopic sinus surgery. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Springer International | - |
dc.relation.isPartOf | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Carboxymethylcellulose Sodium/pharmacology* | - |
dc.subject.MESH | Endoscopy | - |
dc.subject.MESH | Fibrosis/prevention & control | - |
dc.subject.MESH | Hyaluronic Acid/pharmacology* | - |
dc.subject.MESH | Models, Animal | - |
dc.subject.MESH | Nasal Cavity/surgery* | - |
dc.subject.MESH | Nasal Mucosa/injuries | - |
dc.subject.MESH | Nasal Mucosa/pathology | - |
dc.subject.MESH | Nasal Mucosa/surgery | - |
dc.subject.MESH | Rats, Sprague-Dawley | - |
dc.subject.MESH | Tissue Adhesions/prevention & control* | - |
dc.subject.MESH | Viscosupplements/pharmacology* | - |
dc.title | Anti-adhesive effect of solid mixture of sodium hyaluronate/carboxymethylcellulose in murine nasal cavities | - |
dc.type | Article | - |
dc.publisher.location | Germany | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Otorhinolaryngology | - |
dc.contributor.googleauthor | Eun Jung Lee | - |
dc.contributor.googleauthor | Hye Jin Hwang | - |
dc.contributor.googleauthor | Chan Min Jung | - |
dc.contributor.googleauthor | Min Ki Kim | - |
dc.contributor.googleauthor | Kyung-Su Kim | - |
dc.identifier.doi | 10.1007/s00405-016-4186-z | - |
dc.contributor.localId | A03046 | - |
dc.contributor.localId | A00298 | - |
dc.relation.journalcode | J00802 | - |
dc.identifier.eissn | 1434-4726 | - |
dc.identifier.pmid | 27376646 | - |
dc.identifier.url | https://link.springer.com/article/10.1007%2Fs00405-016-4186-z | - |
dc.subject.keyword | Adhesion | - |
dc.subject.keyword | Endoscopic sinus surgery | - |
dc.subject.keyword | Mucosal injury | - |
dc.subject.keyword | Murine model | - |
dc.subject.keyword | Solid mixture of sodium hyaluronate/carboxymethylcellulose | - |
dc.contributor.alternativeName | Kim, Kyung Su | - |
dc.contributor.alternativeName | Lee, Eun Jung | - |
dc.contributor.affiliatedAuthor | Lee, Eun Jung | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Su | - |
dc.citation.title | European Archives of Oto-Rhino-Laryngology | - |
dc.citation.volume | 274 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 181 | - |
dc.citation.endPage | 188 | - |
dc.identifier.bibliographicCitation | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, Vol.274(1) : 181-188, 2017 | - |
dc.date.modified | 2017-11-01 | - |
dc.identifier.rimsid | 41596 | - |
dc.type.rims | ART | - |
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