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Anti-adhesive effect of solid mixture of sodium hyaluronate/carboxymethylcellulose in murine nasal cavities

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dc.contributor.author김경수-
dc.contributor.author이은정-
dc.contributor.author정찬민-
dc.date.accessioned2017-11-02T08:07:11Z-
dc.date.available2017-11-02T08:07:11Z-
dc.date.issued2017-
dc.identifier.issn0937-4477-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154100-
dc.description.abstractThe purpose of the study was to evaluate the effect of a solid mixture of sodium hyaluronate and carboxymethylcellulose (S-HA/CMC) for the prevention of adhesions after iatrogenic mucosal injury in murine nasal cavities. We introduced iatrogenic adhesions into the bilateral nasal cavities of 20 male Sprague-Dawley rats. S-HA/CMC was applied to the left nasal cavity, while no packing was placed in the right nasal cavity as a control. At 1, 2, and 4 weeks post-procedure, we examined the number of adhesions, the ratio of the longest cross-sectional length of adhesion to septal cartilage length (RAC), and the degree of fibrosis. S-HA/CMC significantly reduced the number of adhesions when compared to the control group in total (p = 0.031), but not at each individual time point. The S-HA/CMC group showed significantly shorter RAC than the control group in total (p = 0.044), but not at each individual time point. The total fibrosis score was less severe in the S-HA/CMC group than in the control group (p < 0.001), with a significant difference between the two groups at the second week (p = 0.001). Therefore, in an animal model, S-HA/CMC can prevent post-injury mucosal adhesions suggesting a potential for clinical applications in endoscopic sinus surgery. Further clinical trials are needed to determine the safety and efficacy of S-HA/CMC as nasal packing after endoscopic sinus surgery.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherSpringer International-
dc.relation.isPartOfEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCarboxymethylcellulose Sodium/pharmacology*-
dc.subject.MESHEndoscopy-
dc.subject.MESHFibrosis/prevention & control-
dc.subject.MESHHyaluronic Acid/pharmacology*-
dc.subject.MESHModels, Animal-
dc.subject.MESHNasal Cavity/surgery*-
dc.subject.MESHNasal Mucosa/injuries-
dc.subject.MESHNasal Mucosa/pathology-
dc.subject.MESHNasal Mucosa/surgery-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHTissue Adhesions/prevention & control*-
dc.subject.MESHViscosupplements/pharmacology*-
dc.titleAnti-adhesive effect of solid mixture of sodium hyaluronate/carboxymethylcellulose in murine nasal cavities-
dc.typeArticle-
dc.publisher.locationGermany-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Otorhinolaryngology-
dc.contributor.googleauthorEun Jung Lee-
dc.contributor.googleauthorHye Jin Hwang-
dc.contributor.googleauthorChan Min Jung-
dc.contributor.googleauthorMin Ki Kim-
dc.contributor.googleauthorKyung-Su Kim-
dc.identifier.doi10.1007/s00405-016-4186-z-
dc.contributor.localIdA03046-
dc.contributor.localIdA00298-
dc.relation.journalcodeJ00802-
dc.identifier.eissn1434-4726-
dc.identifier.pmid27376646-
dc.identifier.urlhttps://link.springer.com/article/10.1007%2Fs00405-016-4186-z-
dc.subject.keywordAdhesion-
dc.subject.keywordEndoscopic sinus surgery-
dc.subject.keywordMucosal injury-
dc.subject.keywordMurine model-
dc.subject.keywordSolid mixture of sodium hyaluronate/carboxymethylcellulose-
dc.contributor.alternativeNameKim, Kyung Su-
dc.contributor.alternativeNameLee, Eun Jung-
dc.contributor.affiliatedAuthorLee, Eun Jung-
dc.contributor.affiliatedAuthorKim, Kyung Su-
dc.citation.titleEuropean Archives of Oto-Rhino-Laryngology-
dc.citation.volume274-
dc.citation.number1-
dc.citation.startPage181-
dc.citation.endPage188-
dc.identifier.bibliographicCitationEUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY, Vol.274(1) : 181-188, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid41596-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers

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