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Epigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder

Authors
 T. Y. Kim  ;  S. J. Kim  ;  H. G. Chung  ;  J. H. Choi  ;  S. H. Kim  ;  J. I. Kang 
Citation
 ACTA PSYCHIATRICA SCANDINAVICA, Vol.135(2) : 170-179, 2017 
Journal Title
 ACTA PSYCHIATRICA SCANDINAVICA 
ISSN
 0001-690X 
Issue Date
2017
MeSH
Aged ; Brain-Derived Neurotrophic Factor/genetics* ; Combat Disorders/diagnosis* ; Combat Disorders/genetics ; CpG Islands ; DNA Methylation* ; Epigenesis, Genetic ; Genetic Association Studies ; Genetic Predisposition to Disease ; Humans ; Logistic Models ; Male ; Middle Aged ; Promoter Regions, Genetic* ; Psychiatric Status Rating Scales
Keywords
BDNF ; DNA methylation ; epigenetics ; post-traumatic stress disorder ; trauma
Abstract
OBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays a crucial role in modulating resilience and vulnerability to stress. The aim of this study was to investigate whether epigenetic regulation of the BDNF gene is a biomarker of post-traumatic stress disorder (PTSD) development among veterans exposed to combat in the Vietnam War. METHODS: Using the Clinician-Administered PTSD Scale, combat veterans were grouped into those with (n = 126) and without (n = 122) PTSD. DNA methylation levels at four CpG sites within the BDNF promoter I region were quantified in the peripheral blood using pyrosequencing. The effects of BDNF DNA methylation levels and clinical variables on the diagnosis of PTSD were tested using binary logistic regression analysis. RESULTS: Subjects with PTSD showed a higher DNA methylation of four CpG sites at the BDNF promoter compared with those without PTSD. High methylation levels at the BDNF promoter CpG site, high combat exposure, and alcohol problems were significantly associated with PTSD diagnosis. CONCLUSIONS: This study demonstrated an association between higher DNA methylation of the BDNF promoter and PTSD diagnosis in combat-exposed individuals. Our findings suggest that altered BDNF methylation may be a valuable biomarker of PTSD after trauma exposure.
Full Text
http://onlinelibrary.wiley.com/doi/10.1111/acps.12675/abstract
DOI
10.1111/acps.12675
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154083
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